Detailed information of TA system TA126965

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2127495..2128045
• Replicon: chromosome
• Accession: NZ_CP040798
• Organism: Streptococcus sanguinis strain CGMH058

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FDP16_RS10500
• Protein ID: WP_176799611.1
• Coordinates: 2127767..2128045 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FDP16_RS10495
• Protein ID: WP_176799610.1
• Coordinates: 2127495..2127767 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FDP16_RS10460	2122569..2123279	-	711	WP_176799605.1	metal ABC transporter ATP-binding protein	-
FDP16_RS10465	2123276..2123719	-	444	WP_168956676.1	zinc-dependent MarR family transcriptional regulator	-
FDP16_RS10470	2124231..2124854	-	624	WP_176799606.1	hypothetical protein	-
FDP16_RS10475	2125359..2125715	+	357	WP_176799607.1	hypothetical protein	-
FDP16_RS10480	2125741..2126166	-	426	WP_176799608.1	ImmA/IrrE family metallo-endopeptidase	-
FDP16_RS10485	2126179..2126507	-	329	Protein_2040	helix-turn-helix transcriptional regulator	-
FDP16_RS10490	2126874..2127023	-	150	WP_176799609.1	hypothetical protein	-
FDP16_RS10495	2127495..2127767	+	273	WP_176799610.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FDP16_RS10500	2127767..2128045	+	279	WP_176799611.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FDP16_RS10505	2128350..2129300	+	951	WP_176799612.1	IS30 family transposase	-
FDP16_RS10510	2129527..2130132	+	606	WP_176799613.1	sce7726 family protein	-
FDP16_RS10515	2130127..2131023	-	897	WP_176799614.1	hypothetical protein	-
FDP16_RS10520	2131376..2131962	+	587	Protein_2047	hypothetical protein	-
FDP16_RS10525	2132357..2132524	+	168	WP_176799819.1	TetR family transcriptional regulator	-
FDP16_RS10530	2132527..2132742	+	216	WP_176799615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2095414..2142801	47387

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10964.85 Da
• Isoelectric Point: 8.0385

>T126965 WP_176799611.1 NZ_CP040798:2127767-2128045 [Streptococcus sanguinis]
MYQVKFTSAFKKSYKRMKKRGLELSLLEEVIEKLRLGQPLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEEDILTLTL
TDTGSHADLFKM

Nucleotide

• Length: 279 bp

>T126965 NZ_CP040798:2127767-2128045 [Streptococcus sanguinis]
ATGTATCAAGTTAAATTCACCTCGGCTTTTAAAAAGAGCTATAAACGCATGAAAAAGCGGGGGTTAGAACTTTCACTCCT
GGAGGAAGTGATTGAAAAACTTCGTCTGGGGCAACCACTAGAAGAAAAATACCGTGATCATGAACTCAAAGGAAATTTTG
TAGGGTTTAGGGAGTGTCATATTAAGCCTGATTGGCTTTTGATTTATCTTATTGAAGAAGATATTTTGACACTCACCCTA
ACCGATACAGGCAGTCATGCGGATTTGTTTAAGATGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9821.23 Da
• Isoelectric Point: 4.6895

>AT126965 WP_176799610.1 NZ_CP040798:2127495-2127767 [Streptococcus sanguinis]
MATVPTQIRIDETVKAQANSLFSDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKQISRDETVASYGN
LTDLKKALEG

Nucleotide

• Length: 273 bp

>AT126965 NZ_CP040798:2127495-2127767 [Streptococcus sanguinis]
ATGGCAACTGTACCAACTCAAATTCGGATTGATGAGACCGTAAAAGCCCAAGCAAATTCATTATTTAGTGACTTGGGTAT
GGATATGTCTAGTGCGGTGAATATTTTTCTTCGTCAATGTCTTTTGCGTGGGGGACTTCCTTTCACGGTTGAAGTTCCTA
ATTATAGCCAAAAGACTTTAGAAGCCCTGGCTGAAGCAAAACAGATTTCTCGTGATGAAACGGTCGCTTCTTATGGCAAT
CTGACCGATTTGAAGAAAGCGTTAGAAGGCTGA