Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1475817..1476341 Replicon chromosome
Accession NZ_CP040781
Organism Staphylococcus sp. 17KM0847

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FGL66_RS07210 Protein ID WP_180809167.1
Coordinates 1475817..1476170 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FGL66_RS07215 Protein ID WP_180809168.1
Coordinates 1476171..1476341 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL66_RS07190 1472778..1473548 - 771 WP_180809163.1 RNA polymerase sigma factor SigB -
FGL66_RS07195 1473520..1474002 - 483 WP_180809164.1 anti-sigma B factor RsbW -
FGL66_RS07200 1474004..1474330 - 327 WP_180809165.1 anti-sigma factor antagonist -
FGL66_RS07205 1474407..1475411 - 1005 WP_180809166.1 PP2C family protein-serine/threonine phosphatase -
FGL66_RS07210 1475817..1476170 - 354 WP_180809167.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FGL66_RS07215 1476171..1476341 - 171 WP_180809168.1 antitoxin MazE Antitoxin
FGL66_RS07220 1476431..1477579 - 1149 WP_180809169.1 alanine racemase -
FGL66_RS07225 1477625..1477990 - 366 WP_180809170.1 holo-ACP synthase -
FGL66_RS07230 1477987..1478586 - 600 WP_180809171.1 PH domain-containing protein -
FGL66_RS07235 1478570..1480081 - 1512 WP_180809172.1 PH domain-containing protein -
FGL66_RS07240 1480074..1480550 - 477 WP_180809173.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12925.08 Da        Isoelectric Point: 10.4085

>T126960 WP_180809167.1 NZ_CP040781:c1476170-1475817 [Staphylococcus sp. 17KM0847]
MKRGDVFLADLSPVKGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIDKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSDDKMKEVNNALGISLGLHVNASK

Download         Length: 354 bp

>T126960 NZ_CP040781:c1476170-1475817 [Staphylococcus sp. 17KM0847]
ATGAAGCGTGGTGATGTGTTTCTAGCAGATTTGTCGCCAGTTAAGGGATCTGAGCAAGGGGGAGTAAGACCTGTCGTTAT
CATTCAAAATGATACTGGTAATAAATATAGTCCAACAGTTATTGTAGCAGCGATTACAGGGAGGATTAATAAAGCTAAAA
TTCCGACCCATGTAGAGATAGATAAAAACAAATACAAACTTGATAAAGACTCTGTTATTCTGTTAGAACAAATCAGAACG
GTTGATAAAAAAAGGCTAAAAGAAAAACTTACTTTTTTATCAGACGACAAGATGAAAGAAGTGAACAATGCTTTAGGTAT
TAGTTTAGGTCTTCATGTTAATGCGTCAAAGTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6306.94 Da        Isoelectric Point: 3.9760

>AT126960 WP_180809168.1 NZ_CP040781:c1476341-1476171 [Staphylococcus sp. 17KM0847]
MSVFNQTKFKNLEQSLKEGYAQMADLNLSLATEAYSVECEACDCNESHLLSDKQDD

Download         Length: 171 bp

>AT126960 NZ_CP040781:c1476341-1476171 [Staphylococcus sp. 17KM0847]
ATGTCAGTATTCAATCAAACAAAGTTTAAAAATTTAGAGCAGTCACTGAAGGAAGGTTATGCCCAAATGGCAGATTTGAA
TCTCTCCCTAGCAACAGAAGCCTATTCAGTCGAATGTGAAGCGTGCGATTGTAATGAATCACACTTATTATCAGATAAAC
AGGATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References