Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1383718..1384952 Replicon chromosome
Accession NZ_CP040781
Organism Staphylococcus sp. 17KM0847

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag FGL66_RS06755 Protein ID WP_180809086.1
Coordinates 1383718..1384476 (-) Length 253 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag FGL66_RS06760 Protein ID WP_180809087.1
Coordinates 1384476..1384952 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL66_RS06735 1380353..1381003 - 651 WP_180809083.1 Crp/Fnr family transcriptional regulator -
FGL66_RS06740 1381030..1381308 - 279 WP_180809084.1 iron-sulfur cluster repair di-iron protein, ric -
FGL66_RS06745 1381325..1381552 - 228 WP_180810491.1 cation transporter -
FGL66_RS06750 1381641..1383485 - 1845 WP_180809085.1 heavy metal translocating P-type ATPase -
FGL66_RS06755 1383718..1384476 - 759 WP_180809086.1 zeta toxin family protein Toxin
FGL66_RS06760 1384476..1384952 - 477 WP_180809087.1 helix-turn-helix domain-containing protein Antitoxin
FGL66_RS06765 1385175..1386539 - 1365 WP_180810492.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
FGL66_RS06770 1386639..1387574 - 936 WP_180809088.1 diacylglycerol kinase -
FGL66_RS06775 1387770..1389197 - 1428 WP_180809089.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28655.49 Da        Isoelectric Point: 6.2497

>T126959 WP_180809086.1 NZ_CP040781:c1384476-1383718 [Staphylococcus sp. 17KM0847]
MRLEVFSQEEFTLALKRIIRSLTRGKTPSINPKAFLLGGQSGAGKTTIHRIKQKAFQGNIIIIDGDSYRSLHPNYLALQE
EYGKDSFDSTKRFAGKVVEHLVDALSKQGYHLLIEGTLRTTEVPRKTEQLLKSSGYQVSLVLMATKPELSYLSTLIRYEE
VYSVNSSQARATSKEHHDGIVGSLVDNLRELENDKCFDQIQIYQRDRACIYDSETDEDSATDVLQECLFGKWSKVEEEML
KVGQERLDELKI

Download         Length: 759 bp

>T126959 NZ_CP040781:c1384476-1383718 [Staphylococcus sp. 17KM0847]
ATGAGGTTAGAAGTATTTAGTCAAGAAGAGTTTACTCTAGCCTTAAAACGAATCATTCGTTCCTTAACTCGTGGTAAAAC
ACCATCAATTAACCCAAAAGCCTTTTTACTTGGTGGGCAAAGTGGCGCAGGTAAAACAACAATACACCGTATCAAGCAGA
AAGCGTTTCAAGGGAATATCATCATTATAGATGGTGATAGCTATCGCTCTTTACACCCTAATTATCTAGCTTTACAAGAA
GAATACGGCAAGGATAGCTTTGACTCTACCAAGCGATTTGCAGGAAAAGTAGTGGAACATCTTGTTGATGCGCTAAGTAA
ACAAGGTTATCATTTGTTAATTGAAGGAACTTTAAGAACGACAGAAGTCCCAAGAAAAACTGAACAGCTATTAAAATCAA
GTGGCTACCAAGTCTCATTAGTCTTGATGGCAACTAAGCCTGAATTGTCCTACCTCAGCACCCTAATTCGCTATGAAGAA
GTCTATTCGGTAAATTCGAGTCAAGCTAGAGCAACCTCAAAAGAACATCATGATGGTATTGTAGGGAGCTTGGTAGATAA
CCTAAGGGAGTTAGAAAACGATAAATGCTTTGATCAGATTCAGATTTATCAAAGAGATAGGGCTTGTATTTATGACTCTG
AAACTGATGAAGATTCCGCAACCGATGTTCTACAAGAGTGCCTCTTTGGAAAATGGAGTAAGGTAGAGGAAGAGATGTTG
AAGGTGGGACAAGAACGATTGGATGAGTTAAAAATTTAG

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18207.62 Da        Isoelectric Point: 4.3930

>AT126959 WP_180809087.1 NZ_CP040781:c1384952-1384476 [Staphylococcus sp. 17KM0847]
MIGDNIKSLRRTHELTQPEFAKIVGISRNSLSRYENGTSSVSTELIDHICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
IIKERGAAILSQLYRYQDSQGIAFDDEVNPWILMSDDLSDLINTKIYLVDTFDEIERYNGYLDGIERMLELARHQVVA

Download         Length: 477 bp

>AT126959 NZ_CP040781:c1384952-1384476 [Staphylococcus sp. 17KM0847]
ATGATTGGAGACAATATAAAATCATTACGAAGAACCCATGAATTGACGCAACCAGAATTTGCAAAAATTGTTGGTATCTC
AAGGAATAGTCTGAGTCGTTATGAAAATGGAACAAGTTCTGTTTCAACAGAGCTTATAGACCACATTTGTCAGAAATTCA
ATGTGTCTTATATTGACATTGTAGGAGAAGAAAAGATGTTAACACCAGTAGAAGATTATCAATTGACACTGAAAATAGAA
ATCATAAAAGAACGTGGTGCAGCAATTTTATCTCAATTGTATCGCTATCAAGATAGTCAAGGAATTGCTTTTGATGATGA
GGTCAATCCTTGGATTTTGATGAGTGATGACTTGTCGGATCTTATCAATACAAAGATTTATCTTGTCGATACTTTTGATG
AAATAGAGCGCTACAATGGCTATTTAGATGGTATCGAACGTATGTTAGAGCTTGCTCGTCATCAGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References