Detailed information of TA system TA126953

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1011746..1013213
• Replicon: chromosome
• Accession: NZ_CP040776
• Organism: Mycoplasmopsis bovis strain NADC53

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: Q932V7
• Locus tag: FG865_RS04375
• Protein ID: WP_041309184.1
• Coordinates: 1011746..1012606 (-)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q934C3
• Locus tag: FG865_RS04380
• Protein ID: WP_013456322.1
• Coordinates: 1012599..1013213 (-)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG865_RS04355 (FG865_04270)	1007302..1008330	+	1029	WP_214485684.1	IS30-like element ISMbov1 family transposase	-
FG865_RS04360 (FG865_04275)	1008541..1009548	+	1008	WP_075270934.1	ECF transporter S component	-
FG865_RS04365 (FG865_04285)	1010096..1011007	+	912	WP_214479480.1	variable surface lipoprotein	-
FG865_RS04685	1011275..1011625	-	351	Protein_841	variable surface lipoprotein	-
FG865_RS04375 (FG865_04295)	1011746..1012606	-	861	WP_041309184.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FG865_RS04380 (FG865_04300)	1012599..1013213	-	615	WP_013456322.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FG865_RS04385	1013397..1013996	+	600	WP_235127484.1	variable surface lipoprotein	-
FG865_RS04390	1014555..1014671	-	117	Protein_845	variable surface lipoprotein	-
FG865_RS04395 (FG865_04315)	1014878..1015492	-	615	WP_235127485.1	variable surface lipoprotein	-
FG865_RS04400 (FG865_04320)	1015669..1016313	-	645	WP_214479814.1	variable surface lipoprotein	-
FG865_RS04405	1016479..1017252	-	774	WP_235115272.1	variable surface lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1007212..1008330	1118
	-	flank	IS/Tn	-	-	1017674..1018792	1118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-234)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 33281.35 Da
• Isoelectric Point: 7.2878

>T126953 WP_041309184.1 NZ_CP040776:c1012606-1011746 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADENNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFKAITNSIIELLELIKVNELTNND

Nucleotide

• Length: 861 bp

>T126953 NZ_CP040776:c1012606-1011746 [Mycoplasmopsis bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATGAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGCGATGTCATTACACCTAAGGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTATAACACATTCAAAAATAGGAACAGTGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCGTTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGACTTTAAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGTCAATGAATTAACAAATAATGATTAA

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24143.83 Da
• Isoelectric Point: 9.7617

>AT126953 WP_013456322.1 NZ_CP040776:c1013213-1012599 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

>AT126953 NZ_CP040776:c1013213-1012599 [Mycoplasmopsis bovis]
ATGGAACAAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACTGTTACATAAAAATAACGGTGTTATCACATA
TAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGATAACAAAAGGCGTTCTTATTAGAAGAGCTA
AAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTAAGCAAAAACTATAAATCGTTAATCTTTTCT
CATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCAAATTGACGTTACAGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATAAACATTCAATTGGACTATCTGAATCAAAAA
CATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGTGATTTTGTAAAACTACGCAAGAAAACAGAT
AGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAGAGATTGAAAAAAATTGTATGAATACGCCTA
TGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATGAATAA

Structures

Toxin

• AlphaFold DB: Q932V7

Antitoxin

• AlphaFold DB: Q934C3