Detailed information of TA system TA126952

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 928887..930354
• Replicon: chromosome
• Accession: NZ_CP040775
• Organism: Mycoplasmopsis bovis strain NADC51

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: FG864_RS04030
• Protein ID: WP_214468966.1
• Coordinates: 928887..929747 (-)
• Length: 287 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: Q934C3
• Locus tag: FG864_RS04035
• Protein ID: WP_013456322.1
• Coordinates: 929740..930354 (-)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FG864_RS04005	924016..924171	-	156	WP_180370284.1	hypothetical protein	-
FG864_RS04010 (FG864_03995)	924387..925268	+	882	WP_214484681.1	variable surface lipoprotein	-
FG864_RS04015 (FG864_04000)	925311..926060	-	750	WP_214484689.1	variable surface lipoprotein	-
FG864_RS04020	926765..927418	+	654	WP_235115267.1	variable surface lipoprotein	-
FG864_RS04025	928006..928767	-	762	WP_235115268.1	variable surface lipoprotein	-
FG864_RS04030 (FG864_04020)	928887..929747	-	861	WP_214468966.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FG864_RS04035 (FG864_04025)	929740..930354	-	615	WP_013456322.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
FG864_RS04040	930537..931103	+	567	WP_235115269.1	variable surface lipoprotein	-
FG864_RS04045	931346..931519	+	174	WP_235115270.1	hypothetical protein	-
FG864_RS04050	931782..932381	-	600	WP_235115271.1	variable surface lipoprotein	-
FG864_RS04055	932547..933320	-	774	WP_235115272.1	variable surface lipoprotein	-
FG864_RS04060	933506..934366	-	861	WP_235115273.1	variable surface lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-236)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (13-59)

Sequences

Toxin

Protein

• Length: 287 a.a.
• Molecular weight: 33268.31 Da
• Isoelectric Point: 6.8630

>T126952 WP_214468966.1 NZ_CP040775:c929747-928887 [Mycoplasmopsis bovis]
MNKNKLISLCHKTADENNANFNVVLIQYFMESILRRISKSNERDNFVFKGGFLLSNIMGLDKRATMDIDLELIKTQKISA
SKILEKFKSILNADDIDGIRYHILKYTDIRKEHKYSGINISVLCQIENIKQVISIDIASGDVITPKEIVYEYKSIFSNQD
FSILAYNIETMLSEKLETIFSFGHLNTRFKDFYDVYVIYTFKKKDIDINRLKDACYNTFKNRNSEFNIQQLLELITNIAF
NPLMNERKKYISQIANQQEIDFEAITNSIIELLELIKAKELTNND

Nucleotide

• Length: 861 bp

>T126952 NZ_CP040775:c929747-928887 [Mycoplasmopsis bovis]
ATGAATAAAAATAAATTAATAAGTTTGTGTCATAAAACTGCTGATGAAAATAACGCAAATTTCAATGTTGTTTTAATTCA
ATATTTTATGGAAAGCATTCTACGAAGAATATCTAAAAGTAATGAGAGAGACAATTTTGTGTTCAAGGGCGGTTTTCTTT
TATCTAACATTATGGGGTTAGATAAAAGAGCTACAATGGATATTGATTTGGAGCTAATAAAAACTCAAAAGATAAGTGCT
TCTAAAATATTAGAAAAATTTAAAAGTATATTAAACGCTGATGACATCGATGGAATTAGATATCACATTCTTAAGTATAC
TGACATTCGAAAGGAGCATAAATATAGTGGCATTAACATATCAGTCCTATGTCAAATAGAGAATATAAAACAAGTTATTT
CTATAGATATTGCATCAGGTGATGTCATTACACCTAAAGAAATTGTTTATGAATACAAAAGTATATTTTCAAATCAGGAT
TTTTCTATTTTAGCTTATAACATTGAAACTATGCTATCTGAAAAGCTTGAGACAATATTTTCTTTTGGTCACTTAAATAC
AAGATTTAAAGATTTTTATGATGTTTATGTTATATACACTTTTAAAAAGAAGGACATTGATATTAATAGGCTCAAGGATG
CTTGCTACAACACATTCAAAAATAGAAACAGCGAATTTAACATACAACAATTGTTGGAACTAATTACCAATATTGCTTTC
AATCCATTGATGAATGAAAGATGAAAAAAGTACATAAGTCAGATAGCAAATCAGCAGGAAATAGATTTTGAAGCCATTAC
TAATTCAATAATAGAACTACTAGAACTAATTAAGGCCAAGGAATTAACAAATAATGATTAA

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24143.83 Da
• Isoelectric Point: 9.7617

>AT126952 WP_013456322.1 NZ_CP040775:c930354-929740 [Mycoplasmopsis bovis]
MEQKNLNSKYYNAIFKLLHKNNGVITYKQLKENNISSIYLTRMITKGVLIRRAKGIYILSDGHYDEYYFLSKNYKSLIFS
HYSALYLNNIIDIFPHQIDVTVYSGYNAKGIKKHANVYYCDRNKHSIGLSESKTLFGNKVKVYDFERTICDFVKLRKKTD
SEIFSKLISAYIKYENRDKKLYEYAYELGIHKKISEIFELFYE

Nucleotide

• Length: 615 bp

>AT126952 NZ_CP040775:c930354-929740 [Mycoplasmopsis bovis]
ATGGAACAAAAAAACTTAAATTCGAAATATTACAATGCAATTTTTAAACTGTTACATAAAAATAACGGTGTTATCACATA
TAAGCAACTAAAAGAAAACAATATATCTTCTATATATTTAACAAGAATGATAACAAAAGGCGTTCTTATTAGAAGAGCTA
AAGGCATTTATATTCTTAGTGATGGACATTACGATGAATATTATTTCTTAAGCAAAAACTATAAATCGTTAATCTTTTCT
CATTATAGTGCACTATATTTAAATAATATTATTGACATTTTTCCGCATCAAATTGACGTTACAGTTTACAGTGGCTATAA
TGCAAAAGGCATTAAGAAGCATGCAAATGTTTACTACTGTGATAGGAATAAACATTCAATTGGACTATCTGAATCAAAAA
CATTATTTGGAAACAAAGTTAAGGTATATGACTTTGAGAGAACAATTTGTGATTTTGTAAAACTACGCAAGAAAACAGAT
AGCGAAATCTTTTCTAAGCTTATTAGTGCATATATTAAATATGAAAATAGAGATTGAAAAAAATTGTATGAATACGCCTA
TGAATTAGGCATACACAAAAAAATATCGGAGATATTTGAACTATTTTATGAATAA

Structures

Antitoxin

• AlphaFold DB: Q934C3