Detailed information of TA system TA126950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RelE-RelB
• Location: 92087..92648
• Replicon: plasmid unnamed1
• Accession: NZ_CP040765
• Organism: Paracoccus liaowanqingii strain 2251

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E4191_RS22470
• Protein ID: WP_139616528.1
• Coordinates: 92087..92362 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: E4191_RS22475
• Protein ID: WP_139616529.1
• Coordinates: 92355..92648 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4191_RS22435	87407..88786	-	1380	WP_139616691.1	TolC family protein	-
E4191_RS22440	88807..89025	-	219	WP_139616523.1	hypothetical protein	-
E4191_RS22445	89097..89504	-	408	WP_139616524.1	hypothetical protein	-
E4191_RS22450	89669..90199	-	531	WP_139616692.1	L,D-transpeptidase family protein	-
E4191_RS22455	90229..90870	-	642	WP_139616525.1	DUF411 domain-containing protein	-
E4191_RS22460	90767..91246	-	480	WP_139616526.1	cytochrome c	-
E4191_RS22465	91610..91951	-	342	WP_139616527.1	hypothetical protein	-
E4191_RS22470	92087..92362	-	276	WP_139616528.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E4191_RS22475	92355..92648	-	294	WP_139616529.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4191_RS22480	93149..94420	-	1272	WP_135312179.1	IS256 family transposase	-
E4191_RS22490	94750..94935	-	186	Protein_90	chromate transporter	-
E4191_RS22495	95030..95308	+	279	WP_139616530.1	metal/formaldehyde-sensitive transcriptional repressor	-
E4191_RS22500	95305..96234	+	930	WP_139616531.1	CDF family Co(II)/Ni(II) efflux transporter DmeF	-
E4191_RS23985	96239..96388	-	150	WP_176562859.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..310431	310431
	-	flank	IS/Tn	-	-	93149..94468	1319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-58)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10245.93 Da
• Isoelectric Point: 5.6479

>T126950 WP_139616528.1 NZ_CP040765:c92362-92087 [Paracoccus liaowanqingii]
VPELEWKAFAVADLMAIVDYISDDNPDAALSLMEEIQGKVSQLPMHPKRCRSGRVQGTRELVVRPNYIVIYAETPSVVTI
LRVLHAAQMWP

Nucleotide

• Length: 276 bp

>T126950 NZ_CP040765:c92362-92087 [Paracoccus liaowanqingii]
GTGCCTGAACTCGAATGGAAAGCCTTCGCGGTCGCCGACCTCATGGCAATTGTCGACTATATCTCGGATGACAATCCTGA
TGCTGCTCTTTCTCTGATGGAGGAAATTCAGGGAAAGGTTTCGCAACTTCCAATGCATCCCAAGCGCTGCCGGTCAGGAC
GCGTTCAAGGAACACGTGAATTGGTCGTTCGCCCGAACTACATTGTCATCTATGCTGAGACGCCGTCTGTCGTGACGATC
CTTCGCGTGCTGCATGCCGCGCAGATGTGGCCCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10284.67 Da
• Isoelectric Point: 7.4036

>AT126950 WP_139616529.1 NZ_CP040765:c92648-92355 [Paracoccus liaowanqingii]
MPTHTSMLHVRVDDHLKAQASSALAGVGLTLSDAVRILLTRVAAEGGLPAGLTANPESYDSWFRAKVQEALTDTRAGVPH
DQVIRDARALIDGKRGA

Nucleotide

• Length: 294 bp

>AT126950 NZ_CP040765:c92648-92355 [Paracoccus liaowanqingii]
ATGCCCACGCATACCTCGATGCTGCATGTCCGTGTGGACGATCATCTCAAGGCACAGGCCAGTAGCGCACTGGCAGGTGT
AGGCCTGACCCTATCAGACGCAGTCCGTATCCTGCTGACCCGTGTGGCTGCTGAAGGGGGACTGCCGGCCGGTCTGACTG
CAAATCCTGAAAGCTATGATAGCTGGTTCCGGGCGAAGGTGCAGGAAGCGCTGACAGACACTCGAGCTGGCGTTCCACAT
GACCAGGTCATTCGCGACGCCCGGGCATTGATCGACGGCAAACGGGGTGCCTGA