Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RelE-RelB
Location 92087..92648 Replicon plasmid unnamed1
Accession NZ_CP040765
Organism Paracoccus liaowanqingii strain 2251

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag E4191_RS22470 Protein ID WP_139616528.1
Coordinates 92087..92362 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4191_RS22475 Protein ID WP_139616529.1
Coordinates 92355..92648 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4191_RS22435 87407..88786 - 1380 WP_139616691.1 TolC family protein -
E4191_RS22440 88807..89025 - 219 WP_139616523.1 hypothetical protein -
E4191_RS22445 89097..89504 - 408 WP_139616524.1 hypothetical protein -
E4191_RS22450 89669..90199 - 531 WP_139616692.1 L,D-transpeptidase family protein -
E4191_RS22455 90229..90870 - 642 WP_139616525.1 DUF411 domain-containing protein -
E4191_RS22460 90767..91246 - 480 WP_139616526.1 cytochrome c -
E4191_RS22465 91610..91951 - 342 WP_139616527.1 hypothetical protein -
E4191_RS22470 92087..92362 - 276 WP_139616528.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4191_RS22475 92355..92648 - 294 WP_139616529.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E4191_RS22480 93149..94420 - 1272 WP_135312179.1 IS256 family transposase -
E4191_RS22490 94750..94935 - 186 Protein_90 chromate transporter -
E4191_RS22495 95030..95308 + 279 WP_139616530.1 metal/formaldehyde-sensitive transcriptional repressor -
E4191_RS22500 95305..96234 + 930 WP_139616531.1 CDF family Co(II)/Ni(II) efflux transporter DmeF -
E4191_RS23985 96239..96388 - 150 WP_176562859.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..310431 310431
- flank IS/Tn - - 93149..94468 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10245.93 Da        Isoelectric Point: 5.6479

>T126950 WP_139616528.1 NZ_CP040765:c92362-92087 [Paracoccus liaowanqingii]
VPELEWKAFAVADLMAIVDYISDDNPDAALSLMEEIQGKVSQLPMHPKRCRSGRVQGTRELVVRPNYIVIYAETPSVVTI
LRVLHAAQMWP

Download         Length: 276 bp

>T126950 NZ_CP040765:c92362-92087 [Paracoccus liaowanqingii]
GTGCCTGAACTCGAATGGAAAGCCTTCGCGGTCGCCGACCTCATGGCAATTGTCGACTATATCTCGGATGACAATCCTGA
TGCTGCTCTTTCTCTGATGGAGGAAATTCAGGGAAAGGTTTCGCAACTTCCAATGCATCCCAAGCGCTGCCGGTCAGGAC
GCGTTCAAGGAACACGTGAATTGGTCGTTCGCCCGAACTACATTGTCATCTATGCTGAGACGCCGTCTGTCGTGACGATC
CTTCGCGTGCTGCATGCCGCGCAGATGTGGCCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10284.67 Da        Isoelectric Point: 7.4036

>AT126950 WP_139616529.1 NZ_CP040765:c92648-92355 [Paracoccus liaowanqingii]
MPTHTSMLHVRVDDHLKAQASSALAGVGLTLSDAVRILLTRVAAEGGLPAGLTANPESYDSWFRAKVQEALTDTRAGVPH
DQVIRDARALIDGKRGA

Download         Length: 294 bp

>AT126950 NZ_CP040765:c92648-92355 [Paracoccus liaowanqingii]
ATGCCCACGCATACCTCGATGCTGCATGTCCGTGTGGACGATCATCTCAAGGCACAGGCCAGTAGCGCACTGGCAGGTGT
AGGCCTGACCCTATCAGACGCAGTCCGTATCCTGCTGACCCGTGTGGCTGCTGAAGGGGGACTGCCGGCCGGTCTGACTG
CAAATCCTGAAAGCTATGATAGCTGGTTCCGGGCGAAGGTGCAGGAAGCGCTGACAGACACTCGAGCTGGCGTTCCACAT
GACCAGGTCATTCGCGACGCCCGGGCATTGATCGACGGCAAACGGGGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References