Detailed information of TA system TA126947

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4069882..4070441
• Replicon: chromosome
• Accession: NZ_CP040755
• Organism: Colwellia sp. M166

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FGD67_RS18435
• Protein ID: WP_257172504.1
• Coordinates: 4069882..4070160 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FGD67_RS18440
• Protein ID: WP_257172505.1
• Coordinates: 4070157..4070441 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGD67_RS18385 (FGD67_18195)	4065175..4065756	-	582	WP_257172496.1	transposase	-
FGD67_RS18390 (FGD67_18200)	4065684..4066187	-	504	WP_257172497.1	transposase zinc-binding domain-containing protein	-
FGD67_RS18395 (FGD67_18205)	4066180..4066806	-	627	WP_257172498.1	tyrosine-type recombinase/integrase	-
FGD67_RS18400	4066790..4067092	-	303	WP_257171974.1	site-specific integrase	-
FGD67_RS18405 (FGD67_18210)	4067553..4067699	-	147	Protein_3586	IS110 family transposase	-
FGD67_RS18410	4067744..4067878	+	135	WP_257172499.1	hypothetical protein	-
FGD67_RS18415	4067923..4068024	+	102	WP_257172500.1	transposase	-
FGD67_RS18420 (FGD67_18220)	4068311..4068592	+	282	WP_257172501.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FGD67_RS18425 (FGD67_18225)	4068589..4068882	+	294	WP_257172502.1	type II toxin-antitoxin system RelE/ParE family toxin	-
FGD67_RS18430 (FGD67_18230)	4069101..4069931	+	831	WP_257172503.1	transposase	-
FGD67_RS18435 (FGD67_18235)	4069882..4070160	-	279	WP_257172504.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FGD67_RS18440 (FGD67_18240)	4070157..4070441	-	285	WP_257172505.1	damage-inducible protein J	Antitoxin
FGD67_RS18445 (FGD67_18245)	4071055..4072080	-	1026	WP_257171489.1	IS110 family transposase	-
FGD67_RS18450 (FGD67_18250)	4072919..4073236	+	318	WP_257172506.1	VF530 family protein	-
FGD67_RS18455 (FGD67_18255)	4073581..4074810	-	1230	WP_257172507.1	type III PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	tapT	3964555..4072612	108057
	-	flank	IS/Tn	-	-	4067553..4067678	125

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10937.61 Da
• Isoelectric Point: 4.5468

>T126947 WP_257172504.1 NZ_CP040755:c4070160-4069882 [Colwellia sp. M166]
MIFWEEESLNDREKIFEFLFDFNPNAADKTDQTIEAKVENLLEHPLMGVKRDIFRGRVLIIPEISMIVSYWVDGDTIKIM
RVLHQKQNFPPE

Nucleotide

• Length: 279 bp

>T126947 NZ_CP040755:c4070160-4069882 [Colwellia sp. M166]
ATGATCTTTTGGGAAGAAGAATCACTAAATGATCGTGAAAAAATATTTGAATTTCTTTTTGATTTTAACCCAAATGCAGC
AGACAAAACTGATCAAACTATTGAAGCTAAAGTTGAAAACTTACTAGAACACCCACTAATGGGTGTTAAAAGAGATATTT
TTCGTGGAAGAGTGCTAATCATTCCAGAAATATCAATGATTGTTTCTTATTGGGTCGATGGTGATACGATTAAAATAATG
CGAGTTTTACACCAAAAGCAGAATTTCCCACCAGAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.21 Da
• Isoelectric Point: 5.7712

>AT126947 WP_257172505.1 NZ_CP040755:c4070441-4070157 [Colwellia sp. M166]
MDTRIQFRVDEETKRLAQLMAESQGRTLSDACRELAEGLAEEQRKTMSHDAWLSEQINAAFDKFDNGKADFIVHDEAKTL
MEARKQKIRNRDKS

Nucleotide

• Length: 285 bp

>AT126947 NZ_CP040755:c4070441-4070157 [Colwellia sp. M166]
ATGGACACTCGCATTCAATTTAGAGTTGATGAAGAAACAAAACGTTTGGCGCAACTAATGGCCGAAAGCCAAGGTCGCAC
TCTTAGCGACGCATGCCGAGAACTCGCAGAAGGTTTAGCAGAAGAACAGAGAAAAACGATGAGCCATGATGCATGGTTAT
CGGAACAAATAAATGCAGCATTTGACAAGTTTGATAATGGAAAAGCTGATTTTATTGTACATGATGAAGCAAAAACATTA
ATGGAAGCAAGAAAACAGAAAATCCGTAATAGAGACAAATCATGA