Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 4068311..4068882 Replicon chromosome
Accession NZ_CP040755
Organism Colwellia sp. M166

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FGD67_RS18425 Protein ID WP_257172502.1
Coordinates 4068589..4068882 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FGD67_RS18420 Protein ID WP_257172501.1
Coordinates 4068311..4068592 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGD67_RS18370 (FGD67_18180) 4063501..4064106 - 606 WP_257172493.1 site-specific integrase -
FGD67_RS18375 (FGD67_18185) 4064277..4064537 - 261 WP_257172494.1 Txe/YoeB family addiction module toxin -
FGD67_RS18380 (FGD67_18190) 4064534..4064785 - 252 WP_257172495.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
FGD67_RS18385 (FGD67_18195) 4065175..4065756 - 582 WP_257172496.1 transposase -
FGD67_RS18390 (FGD67_18200) 4065684..4066187 - 504 WP_257172497.1 transposase zinc-binding domain-containing protein -
FGD67_RS18395 (FGD67_18205) 4066180..4066806 - 627 WP_257172498.1 tyrosine-type recombinase/integrase -
FGD67_RS18400 4066790..4067092 - 303 WP_257171974.1 site-specific integrase -
FGD67_RS18405 (FGD67_18210) 4067553..4067699 - 147 Protein_3586 IS110 family transposase -
FGD67_RS18410 4067744..4067878 + 135 WP_257172499.1 hypothetical protein -
FGD67_RS18415 4067923..4068024 + 102 WP_257172500.1 transposase -
FGD67_RS18420 (FGD67_18220) 4068311..4068592 + 282 WP_257172501.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FGD67_RS18425 (FGD67_18225) 4068589..4068882 + 294 WP_257172502.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGD67_RS18430 (FGD67_18230) 4069101..4069931 + 831 WP_257172503.1 transposase -
FGD67_RS18435 (FGD67_18235) 4069882..4070160 - 279 WP_257172504.1 type II toxin-antitoxin system RelE/ParE family toxin -
FGD67_RS18440 (FGD67_18240) 4070157..4070441 - 285 WP_257172505.1 damage-inducible protein J -
FGD67_RS18445 (FGD67_18245) 4071055..4072080 - 1026 WP_257171489.1 IS110 family transposase -
FGD67_RS18450 (FGD67_18250) 4072919..4073236 + 318 WP_257172506.1 VF530 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tapT 3964555..4072612 108057
- flank IS/Tn - - 4067553..4067678 125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11080.74 Da        Isoelectric Point: 4.6702

>T126946 WP_257172502.1 NZ_CP040755:4068589-4068882 [Colwellia sp. M166]
MKVVWSPLALEKLEVSAKFIALDKPSAADKWVNDVFDRTDLLGSQPELGREVPELSGSNYREVIFGSYRIIYKVENEVKI
LTLRNSRQLLSLDDIEL

Download         Length: 294 bp

>T126946 NZ_CP040755:4068589-4068882 [Colwellia sp. M166]
TTGAAAGTAGTTTGGTCACCTTTAGCGTTAGAAAAACTAGAAGTGTCTGCTAAGTTTATTGCGCTTGATAAACCATCGGC
TGCAGACAAATGGGTTAATGATGTTTTTGATCGCACTGACTTACTCGGTTCTCAACCTGAATTAGGCCGAGAAGTGCCAG
AGTTGTCAGGTTCAAATTATCGTGAAGTGATATTTGGTAGTTATCGTATTATCTATAAAGTTGAAAATGAAGTTAAAATA
CTAACTTTACGTAATAGTCGTCAGTTGCTTAGTTTGGATGATATTGAGTTATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10308.72 Da        Isoelectric Point: 5.1053

>AT126946 WP_257172501.1 NZ_CP040755:4068311-4068592 [Colwellia sp. M166]
MTRLHFDQDIQPLSDFRAGAASFIRQINETRRPIVITQRGKGVAVVVDVAEYESMQEKIELLEEVQKAEAQLSAGLGISN
SDARAQILKSINP

Download         Length: 282 bp

>AT126946 NZ_CP040755:4068311-4068592 [Colwellia sp. M166]
ATGACTAGACTTCATTTTGATCAAGATATTCAACCACTTTCTGATTTTAGAGCTGGTGCAGCGTCATTTATTCGTCAAAT
TAACGAAACAAGAAGACCAATTGTGATAACACAAAGAGGAAAAGGTGTGGCTGTAGTTGTCGATGTGGCAGAATATGAGT
CAATGCAGGAAAAAATTGAATTACTTGAAGAAGTACAAAAAGCTGAAGCTCAACTTTCTGCTGGATTAGGTATTTCTAAT
TCTGATGCTCGCGCACAAATTTTAAAGAGTATTAATCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References