Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 4064277..4064785 Replicon chromosome
Accession NZ_CP040755
Organism Colwellia sp. M166

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FGD67_RS18375 Protein ID WP_257172494.1
Coordinates 4064277..4064537 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FGD67_RS18380 Protein ID WP_257172495.1
Coordinates 4064534..4064785 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGD67_RS18335 4059657..4059959 - 303 WP_257171974.1 site-specific integrase -
FGD67_RS18340 (FGD67_18160) 4060156..4060620 + 465 WP_257172487.1 hypothetical protein -
FGD67_RS18345 4060617..4061357 + 741 WP_257172488.1 hypothetical protein -
FGD67_RS18350 (FGD67_18165) 4061497..4061745 + 249 WP_257172489.1 hypothetical protein -
FGD67_RS18355 (FGD67_18170) 4062031..4062666 - 636 WP_257172490.1 transposase -
FGD67_RS18360 (FGD67_18175) 4062707..4063204 - 498 WP_257172491.1 transposase zinc-binding domain-containing protein -
FGD67_RS18365 4063197..4063556 - 360 WP_257172492.1 tyrosine-type recombinase/integrase -
FGD67_RS18370 (FGD67_18180) 4063501..4064106 - 606 WP_257172493.1 site-specific integrase -
FGD67_RS18375 (FGD67_18185) 4064277..4064537 - 261 WP_257172494.1 Txe/YoeB family addiction module toxin Toxin
FGD67_RS18380 (FGD67_18190) 4064534..4064785 - 252 WP_257172495.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FGD67_RS18385 (FGD67_18195) 4065175..4065756 - 582 WP_257172496.1 transposase -
FGD67_RS18390 (FGD67_18200) 4065684..4066187 - 504 WP_257172497.1 transposase zinc-binding domain-containing protein -
FGD67_RS18395 (FGD67_18205) 4066180..4066806 - 627 WP_257172498.1 tyrosine-type recombinase/integrase -
FGD67_RS18400 4066790..4067092 - 303 WP_257171974.1 site-specific integrase -
FGD67_RS18405 (FGD67_18210) 4067553..4067699 - 147 Protein_3586 IS110 family transposase -
FGD67_RS18410 4067744..4067878 + 135 WP_257172499.1 hypothetical protein -
FGD67_RS18415 4067923..4068024 + 102 WP_257172500.1 transposase -
FGD67_RS18420 (FGD67_18220) 4068311..4068592 + 282 WP_257172501.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FGD67_RS18425 (FGD67_18225) 4068589..4068882 + 294 WP_257172502.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tapT 3964555..4072612 108057
- flank IS/Tn - - 4067553..4067678 125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10316.85 Da        Isoelectric Point: 10.1736

>T126945 WP_257172494.1 NZ_CP040755:c4064537-4064277 [Colwellia sp. M166]
VKLTFSTKAWEQYLYWQTTDKKILKRVNLLIKDIQRTPNEGIGKPEPLKHGLSGYWSRRINDEHRIVYKQQDDTILIAQL
RYHYGT

Download         Length: 261 bp

>T126945 NZ_CP040755:c4064537-4064277 [Colwellia sp. M166]
GTGAAACTCACTTTTTCAACTAAGGCCTGGGAACAATATCTATACTGGCAAACTACTGACAAAAAAATACTTAAACGCGT
CAATTTGCTCATTAAAGATATCCAAAGAACGCCAAATGAGGGCATTGGAAAACCTGAGCCATTAAAGCACGGGTTATCAG
GCTATTGGTCTCGTCGAATTAATGATGAGCATCGCATCGTATACAAACAGCAAGATGATACAATTCTAATTGCTCAACTG
CGCTACCACTACGGCACATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9074.23 Da        Isoelectric Point: 4.3010

>AT126945 WP_257172495.1 NZ_CP040755:c4064785-4064534 [Colwellia sp. M166]
MDAISYTAARANLANTMANVCNDHAPVIITRKSEAPVVMMSLEDYNSMQETTYLLRSPANARSLLDSIAELEAGNGTQRE
LIE

Download         Length: 252 bp

>AT126945 NZ_CP040755:c4064785-4064534 [Colwellia sp. M166]
ATGGATGCAATAAGCTACACAGCAGCTAGAGCAAATTTAGCAAACACAATGGCGAATGTTTGTAATGATCATGCGCCAGT
TATTATAACTCGTAAAAGTGAAGCTCCTGTTGTGATGATGTCTCTAGAAGACTATAACTCAATGCAAGAAACTACATATT
TACTCAGATCTCCAGCTAACGCTAGAAGCTTACTTGATTCTATTGCCGAACTTGAAGCTGGCAATGGCACTCAAAGAGAG
CTTATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References