Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 883705..884258 Replicon chromosome
Accession NZ_CP040755
Organism Colwellia sp. M166

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag FGD67_RS04035 Protein ID WP_257173806.1
Coordinates 883944..884258 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag FGD67_RS04030 Protein ID WP_257173805.1
Coordinates 883705..883944 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGD67_RS03990 879158..879302 - 145 Protein_775 DUF998 domain-containing protein -
FGD67_RS03995 (FGD67_03925) 879522..879980 - 459 WP_257173801.1 GNAT family N-acetyltransferase -
FGD67_RS04000 (FGD67_03930) 880110..880529 - 420 WP_257173802.1 GNAT family N-acetyltransferase -
FGD67_RS04005 880695..880796 + 102 WP_257173803.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FGD67_RS04010 (FGD67_03935) 880750..880944 + 195 WP_257175204.1 hypothetical protein -
FGD67_RS04015 (FGD67_03940) 881175..882344 + 1170 WP_257172610.1 IS3 family transposase -
FGD67_RS04020 (FGD67_03945) 882373..882629 - 257 Protein_781 type II toxin-antitoxin system RelE/ParE family toxin -
FGD67_RS04025 (FGD67_03950) 882941..883537 - 597 WP_257173804.1 hypothetical protein -
FGD67_RS04030 (FGD67_03955) 883705..883944 + 240 WP_257173805.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FGD67_RS04035 (FGD67_03960) 883944..884258 + 315 WP_257173806.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGD67_RS04045 (FGD67_03970) 885875..886072 - 198 WP_257175061.1 transposase -
FGD67_RS04050 886205..886375 - 171 WP_257173807.1 hypothetical protein -
FGD67_RS04055 (FGD67_03975) 886853..887164 - 312 WP_257173808.1 hypothetical protein -
FGD67_RS04060 (FGD67_03980) 887670..888644 - 975 WP_257173809.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 881175..893588 12413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12152.11 Da        Isoelectric Point: 10.1017

>T126944 WP_257173806.1 NZ_CP040755:883944-884258 [Colwellia sp. M166]
MNKFLLSSKAKIDLIKIARYSQLTWGIPQRNDYLKVLDSTFQLLANEPESGLNCDYIREGYSKYSQASHVIYYKKYKNNQ
IFIVRILHKSMDVNTALKKNITSL

Download         Length: 315 bp

>T126944 NZ_CP040755:883944-884258 [Colwellia sp. M166]
ATGAATAAATTTTTACTGTCTTCGAAAGCCAAAATAGATTTAATTAAAATAGCTAGATATAGCCAATTAACTTGGGGAAT
ACCTCAACGGAACGATTACCTAAAAGTATTAGATAGCACATTTCAGCTGTTAGCTAATGAACCCGAGTCAGGGCTCAATT
GTGATTACATTAGAGAGGGCTACAGCAAATATTCACAAGCTAGCCATGTGATTTATTACAAAAAGTATAAAAACAACCAA
ATTTTTATAGTGCGTATATTACATAAAAGTATGGACGTTAACACCGCACTCAAGAAAAATATAACGAGCCTGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8952.04 Da        Isoelectric Point: 5.0053

>AT126944 WP_257173805.1 NZ_CP040755:883705-883944 [Colwellia sp. M166]
MAKNTSVTLGDHFDQFIKQQLNTGRYGSASEVVRAGLRVLEDQEAKLLNLRNMLIQGEQSGVIDYSYENLLIELDKNNH

Download         Length: 240 bp

>AT126944 NZ_CP040755:883705-883944 [Colwellia sp. M166]
ATGGCTAAAAACACAAGCGTAACATTAGGTGATCATTTTGATCAGTTTATAAAACAACAACTTAACACTGGTCGTTATGG
CTCAGCAAGTGAAGTTGTTAGAGCTGGATTAAGAGTGTTAGAAGATCAAGAAGCTAAACTTTTAAACTTACGCAATATGC
TAATCCAAGGCGAACAAAGCGGCGTTATCGATTACAGCTATGAAAATTTGTTGATTGAGCTAGATAAAAATAACCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References