Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 536075..536711 Replicon chromosome
Accession NZ_CP040747
Organism Bacillus altitudinis strain HQ-51-Ba

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag FED49_RS02635 Protein ID WP_003214169.1
Coordinates 536361..536711 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag FED49_RS02630 Protein ID WP_003214273.1
Coordinates 536075..536356 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FED49_RS02610 532229..532834 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
FED49_RS02615 532929..533294 + 366 WP_017358398.1 holo-ACP synthase -
FED49_RS02620 533455..534471 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
FED49_RS02625 534600..535781 + 1182 WP_046527091.1 alanine racemase -
FED49_RS02630 536075..536356 + 282 WP_003214273.1 hypothetical protein Antitoxin
FED49_RS02635 536361..536711 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
FED49_RS02640 536826..537656 + 831 WP_017358395.1 STAS domain-containing protein -
FED49_RS02645 537661..538029 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
FED49_RS02650 538032..538433 + 402 WP_003214085.1 anti-sigma regulatory factor -
FED49_RS02655 538444..539451 + 1008 WP_008346904.1 PP2C family protein-serine/threonine phosphatase -
FED49_RS02660 539511..539840 + 330 WP_007496474.1 anti-sigma factor antagonist -
FED49_RS02665 539837..540325 + 489 WP_007496471.1 anti-sigma B factor RsbW -
FED49_RS02670 540291..541079 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
FED49_RS02675 541079..541678 + 600 WP_024719202.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T126939 WP_003214169.1 NZ_CP040747:536361-536711 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T126939 NZ_CP040747:536361-536711 [Bacillus altitudinis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCGGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTAATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTGGAACAGATT
CGTACGATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT126939 WP_003214273.1 NZ_CP040747:536075-536356 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT126939 NZ_CP040747:536075-536356 [Bacillus altitudinis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAAATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References