Detailed information of TA system TA126928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1783512..1783980
• Replicon: chromosome
• Accession: NZ_CP040732
• Organism: Staphylococcus hominis strain S34-1

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A4Q9WRX6
• Locus tag: FGY92_RS08805
• Protein ID: WP_017175887.1
• Coordinates: 1783792..1783980 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A4Q9WS45
• Locus tag: FGY92_RS08800
• Protein ID: WP_017175886.1
• Coordinates: 1783512..1783769 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGY92_RS08760 (FGY92_08810)	1778596..1778919	+	324	WP_048682682.1	thioredoxin family protein	-
FGY92_RS08765 (FGY92_08815)	1778957..1779496	-	540	WP_002448165.1	nitroreductase	-
FGY92_RS08770 (FGY92_08820)	1779566..1780291	-	726	WP_048761457.1	type I 3-dehydroquinate dehydratase	-
FGY92_RS08775 (FGY92_08825)	1780453..1780875	+	423	WP_002448074.1	organic hydroperoxide resistance protein	-
FGY92_RS08780 (FGY92_08830)	1781322..1781813	+	492	WP_048761455.1	GNAT family N-acetyltransferase	-
FGY92_RS08785 (FGY92_08835)	1781828..1782427	-	600	WP_019835711.1	histidine phosphatase family protein	-
FGY92_RS08790 (FGY92_08840)	1782622..1782864	+	243	WP_017175884.1	hypothetical protein	-
FGY92_RS08795 (FGY92_08845)	1782856..1783059	-	204	WP_017175885.1	sterile alpha motif-like domain-containing protein	-
FGY92_RS08800 (FGY92_08850)	1783512..1783769	+	258	WP_017175886.1	hypothetical protein	Antitoxin
FGY92_RS08805 (FGY92_08855)	1783792..1783980	+	189	WP_017175887.1	hypothetical protein	Toxin
FGY92_RS08810 (FGY92_08860)	1784149..1784643	+	495	WP_231103779.1	lipoprotein N-acylation protein LnsA	-
FGY92_RS08815 (FGY92_08865)	1784717..1785463	+	747	WP_049379259.1	poly-gamma-glutamate hydrolase family protein	-
FGY92_RS08820 (FGY92_08870)	1785540..1785824	+	285	WP_019835715.1	hypothetical protein	-
FGY92_RS08825 (FGY92_08875)	1785980..1786207	+	228	WP_019835716.1	hypothetical protein	-
FGY92_RS08830 (FGY92_08880)	1786340..1787065	+	726	WP_061544458.1	hypothetical protein	-
FGY92_RS08835	1787201..1787377	+	177	WP_019835718.1	hypothetical protein	-
FGY92_RS08840 (FGY92_08885)	1787432..1788373	-	942	WP_019835719.1	cation diffusion facilitator family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (68-156)

Antitoxin

• Vibrio phage ICP1, Orf50 (19-96)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7050.70 Da
• Isoelectric Point: 9.6269

>T126928 WP_017175887.1 NZ_CP040732:1783792-1783980 [Staphylococcus hominis]
MSTHLTILLWLGIIFVVAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVLIFGIL

Nucleotide

• Length: 189 bp

>T126928 NZ_CP040732:1783792-1783980 [Staphylococcus hominis]
ATGAGTACACATTTAACGATTTTACTTTGGCTCGGTATTATATTTGTTGTTGCTGCTTCAATTATATTAGGGTTATTGCT
AAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGCTTTACAGTCATCTTTTATATTTTTGGTTTTGCTTTACTGA
TATATGTACTAATATTTGGTATTTTATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10069.23 Da
• Isoelectric Point: 4.4986

>AT126928 WP_017175886.1 NZ_CP040732:1783512-1783769 [Staphylococcus hominis]
MNINKLFWINIMITLLFLGFNITVTYFPKLDDYFWLIPGLIICGLTISFSLIAAILDKNLISEIIFLTNLIIFLYYIYPL
IYNFF

Nucleotide

• Length: 258 bp

>AT126928 NZ_CP040732:1783512-1783769 [Staphylococcus hominis]
ATGAATATTAATAAATTATTTTGGATTAATATTATGATTACCCTTTTATTTCTAGGTTTTAATATTACTGTCACCTATTT
TCCTAAGTTAGATGATTATTTTTGGCTCATACCTGGTTTAATCATATGTGGCCTTACTATTTCATTCAGTTTAATTGCCG
CTATTTTGGATAAAAACCTTATAAGCGAAATAATTTTTTTAACTAATCTAATCATTTTTTTATATTATATATATCCACTG
ATATATAACTTTTTTTAA

Structures

Toxin

• AlphaFold DB: A0A4Q9WRX6

Antitoxin

• AlphaFold DB: A0A4Q9WS45