Detailed information of TA system TA126927

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 934075..934870
• Replicon: chromosome
• Accession: NZ_CP040732
• Organism: Staphylococcus hominis strain S34-1

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: FGY92_RS04705
• Protein ID: WP_249339582.1
• Coordinates: 934697..934870 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A4Q9WMK1
• Locus tag: FGY92_RS04700
• Protein ID: WP_017176400.1
• Coordinates: 934075..934674 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGY92_RS04680 (FGY92_04740)	929890..931344	+	1455	WP_235063344.1	ABC transporter substrate-binding protein/permease	-
FGY92_RS04685 (FGY92_04745)	931337..932059	+	723	WP_049382474.1	amino acid ABC transporter ATP-binding protein	-
FGY92_RS04690 (FGY92_04750)	932321..933442	+	1122	WP_017176402.1	tRNA epoxyqueuosine(34) reductase QueG	-
FGY92_RS04695 (FGY92_04755)	933445..933915	+	471	WP_017176401.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
FGY92_RS04700 (FGY92_04760)	934075..934674	+	600	WP_017176400.1	glucosamine-6-phosphate isomerase	Antitoxin
FGY92_RS04705 (FGY92_04765)	934697..934870	+	174	WP_249339582.1	SAS053 family protein	Toxin
FGY92_RS04710 (FGY92_04770)	934981..935373	+	393	WP_017176398.1	hypothetical protein	-
FGY92_RS04715 (FGY92_04775)	935513..936898	+	1386	WP_235063345.1	class II fumarate hydratase	-
FGY92_RS04720 (FGY92_04780)	936977..937801	-	825	WP_019835689.1	RluA family pseudouridine synthase	-
FGY92_RS04725 (FGY92_04785)	937939..939048	+	1110	WP_017176395.1	GAF domain-containing sensor histidine kinase	-
FGY92_RS04730 (FGY92_04790)	939063..939686	+	624	WP_017176394.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6739.15 Da
• Isoelectric Point: 3.9837

>T126927 WP_249339582.1 NZ_CP040732:934697-934870 [Staphylococcus hominis]
IFMSKDSKRNYHEDENAMVQNMDDLEALGKEMEQISEENDEDKYNQTHDSEARSDLN

Nucleotide

• Length: 174 bp

>T126927 NZ_CP040732:934697-934870 [Staphylococcus hominis]
ATTTTTATGAGTAAAGATAGTAAACGTAATTATCATGAAGACGAAAATGCAATGGTTCAAAATATGGATGATTTAGAAGC
ATTAGGAAAAGAAATGGAACAGATTTCTGAAGAAAATGATGAAGATAAATATAATCAAACACATGATTCAGAAGCGCGTT
CAGATTTAAATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22375.22 Da
• Isoelectric Point: 4.9712

>AT126927 WP_017176400.1 NZ_CP040732:934075-934674 [Staphylococcus hominis]
MAMNFKVFEDKQHAADYAGDIIRKQFNNNPTTIAGFHLNKDSAPVLDELKKSVDRNAVDFSQINILDYDDNHSFYEALGV
PSEQVYSISLDDDAESLINDRIKTKENKGKLTLQVVSIDNSGHLDVNIRQGLMKAREIILVVTGAEKSEVIKRLYEENGK
SNFLPADLKVHRMVTVVLDRAAADGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT126927 NZ_CP040732:934075-934674 [Staphylococcus hominis]
ATGGCAATGAATTTTAAAGTATTCGAAGATAAACAACATGCAGCAGACTATGCTGGAGATATTATTAGAAAACAATTTAA
CAATAACCCAACTACCATTGCTGGTTTCCATTTAAACAAGGATTCTGCACCTGTATTAGATGAATTAAAAAAATCAGTTG
ATCGTAACGCTGTAGATTTTAGTCAAATTAATATTCTTGACTATGACGATAATCATTCGTTCTATGAAGCTTTAGGTGTA
CCTTCTGAGCAAGTATATTCTATTAGTCTTGATGATGATGCTGAATCATTAATCAATGATAGAATTAAAACAAAAGAAAA
TAAAGGAAAACTTACTTTACAAGTTGTTTCAATTGATAACTCTGGACATTTAGATGTTAATATTCGTCAAGGTTTGATGA
AGGCACGCGAAATTATCTTAGTTGTAACTGGTGCTGAAAAAAGTGAAGTTATCAAACGATTATATGAAGAAAATGGTAAA
TCAAACTTTTTACCTGCTGATTTAAAAGTACATCGTATGGTAACAGTTGTTTTAGACAGAGCTGCTGCTGATGGATTACC
GGAAGACGTTAAAGAATACTTCACAGCGAGATTTGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A4Q9WMK1