Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 804931..805460 Replicon chromosome
Accession NZ_CP040732
Organism Staphylococcus hominis strain S34-1

Toxin (Protein)


Gene name mazF Uniprot ID A0A4Q9WNP6
Locus tag FGY92_RS03930 Protein ID WP_017174798.1
Coordinates 805098..805460 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1L8Y5N2
Locus tag FGY92_RS03925 Protein ID WP_002448681.1
Coordinates 804931..805101 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGY92_RS03900 (FGY92_03980) 800830..801309 + 480 WP_017174793.1 PH domain-containing protein -
FGY92_RS03905 (FGY92_03985) 801299..802801 + 1503 WP_235063365.1 PH domain-containing protein -
FGY92_RS03910 (FGY92_03990) 802794..803276 + 483 WP_049417165.1 PH domain-containing protein -
FGY92_RS03915 (FGY92_03995) 803304..803657 + 354 WP_017174796.1 holo-ACP synthase -
FGY92_RS03920 (FGY92_04000) 803700..804845 + 1146 WP_048787778.1 alanine racemase -
FGY92_RS03925 (FGY92_04005) 804931..805101 + 171 WP_002448681.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
FGY92_RS03930 (FGY92_04010) 805098..805460 + 363 WP_017174798.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FGY92_RS03935 (FGY92_04015) 805832..806833 + 1002 WP_017174799.1 PP2C family protein-serine/threonine phosphatase -
FGY92_RS03940 (FGY92_04020) 806919..807245 + 327 WP_002448686.1 anti-sigma factor antagonist -
FGY92_RS03945 (FGY92_04025) 807274..807726 + 453 WP_049335593.1 anti-sigma B factor RsbW -
FGY92_RS03950 (FGY92_04030) 807701..808471 + 771 WP_017174800.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - groEL 486498..928260 441762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13580.74 Da        Isoelectric Point: 9.8760

>T126926 WP_017174798.1 NZ_CP040732:805098-805460 [Staphylococcus hominis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDDALDISLGLHDVRPQKN

Download         Length: 363 bp

>T126926 NZ_CP040732:805098-805460 [Staphylococcus hominis]
ATGATTAGAAGAGGCGATGTATATTTAGCTGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTAATCGTTGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACACATGTAGAAATAGAAAAGAAAAAATATCGTTTAGATAAAGATTCAGTCATTCTTTTAGAACAAATACGA
ACATTGGATAAAAAAAGATTGAAAGAGAAACTTACATATTTATCAGAAGATAAAATGAAAGAAGTTGACGATGCATTGGA
TATCAGTTTAGGTTTACACGATGTTCGTCCTCAAAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6368.03 Da        Isoelectric Point: 4.0121

>AT126926 WP_002448681.1 NZ_CP040732:804931-805101 [Staphylococcus hominis]
MLTFNQNRSHSLEQSLKEGYVQMADLNLSLATEAFPLECEACDCNESYLTSNYKSE

Download         Length: 171 bp

>AT126926 NZ_CP040732:804931-805101 [Staphylococcus hominis]
ATGTTAACTTTTAATCAGAATAGAAGCCATAGTCTTGAACAATCATTAAAAGAGGGCTATGTCCAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCATTTCCATTAGAATGTGAAGCTTGTGATTGTAACGAATCATATCTTACATCTAATTATA
AAAGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q9WNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5N2

References