Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 793909..794427 Replicon chromosome
Accession NZ_CP040732
Organism Staphylococcus hominis strain S34-1

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3S7GWQ7
Locus tag FGY92_RS03870 Protein ID WP_017174788.1
Coordinates 794218..794427 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A1L8Y5R0
Locus tag FGY92_RS03865 Protein ID WP_002437530.1
Coordinates 793909..794202 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGY92_RS03840 (FGY92_03920) 789134..789922 + 789 WP_017175143.1 hydroxyethylthiazole kinase -
FGY92_RS03845 (FGY92_03925) 789925..790563 + 639 WP_048787784.1 thiamine phosphate synthase -
FGY92_RS03850 (FGY92_03930) 790653..791522 + 870 WP_002455066.1 membrane protein insertase YidC -
FGY92_RS03855 (FGY92_03935) 791580..792227 - 648 WP_017174786.1 HD domain-containing protein -
FGY92_RS03860 (FGY92_03940) 792262..793746 - 1485 WP_017174787.1 cardiolipin synthase -
FGY92_RS03865 (FGY92_03945) 793909..794202 + 294 WP_002437530.1 copper-sensing transcriptional repressor CsoR Antitoxin
FGY92_RS03870 (FGY92_03950) 794218..794427 + 210 WP_017174788.1 heavy metal-associated domain-containing protein Toxin
FGY92_RS03875 (FGY92_03955) 794540..794677 + 138 WP_002437525.1 Lmo0850 family protein -
FGY92_RS03880 (FGY92_03960) 794838..796022 - 1185 WP_048787782.1 FtsW/RodA/SpoVE family cell cycle protein -
FGY92_RS03885 (FGY92_03965) 796398..797468 + 1071 WP_017174790.1 D-alanine--D-alanine ligase -
FGY92_RS03890 (FGY92_03970) 797484..798839 + 1356 WP_017174791.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside SCCmec - groEL 486498..928260 441762


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-67)

Antitoxin

Metal-sensitive transcriptional repressor

(16-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 8013.16 Da        Isoelectric Point: 4.3178

>T126925 WP_017174788.1 NZ_CP040732:794218-794427 [Staphylococcus hominis]
MLNRNIVFIDNIETKEQAQMLNERLLNMIGVHTVSIDIERNMVNVEYETPTNLNSIEKEIYDAGFKVLS

Download         Length: 210 bp

>T126925 NZ_CP040732:794218-794427 [Staphylococcus hominis]
ATGTTAAACCGTAATATTGTATTTATAGATAACATTGAAACAAAGGAACAAGCACAAATGTTAAATGAACGTTTGTTAAA
TATGATTGGAGTACATACGGTATCAATCGATATAGAAAGAAATATGGTTAATGTTGAATATGAAACACCTACTAATTTAA
ATAGTATTGAAAAAGAAATTTATGACGCTGGATTTAAAGTACTTTCATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11231.84 Da        Isoelectric Point: 6.3270

>AT126925 WP_002437530.1 NZ_CP040732:793909-794202 [Staphylococcus hominis]
MENQNHAHHSEQVKLNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLEHHMKSCIMEKINQGTE
EEAMEELLVTFQKLVKD

Download         Length: 294 bp

>AT126925 NZ_CP040732:793909-794202 [Staphylococcus hominis]
TTGGAAAATCAAAATCATGCCCATCATTCTGAGCAAGTTAAATTAAATTTAAAATCTCGATTAAATCGAATAGAAGGACA
AGTTAAAGCAATTAATCGAATGATTGATGAAGACGTCTACTGTGATGATGTATTAACTCAGATAAGAGCAACACGTTCAG
CACTTAATAGTGTTGCTACTAAGTTACTAGAACATCACATGAAAAGTTGTATTATGGAAAAAATAAATCAAGGTACTGAA
GAAGAAGCAATGGAAGAACTACTAGTGACATTTCAAAAACTAGTGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S7GWQ7

Antitoxin

Source ID Structure
AlphaFold DB A0A1L8Y5R0

References