126922

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 74803..75325 Replicon plasmid pKpvST147B_virulence
Accession NZ_CP040726
Organism Klebsiella pneumoniae strain KpvST147B_SE1_1_NDM

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag FGF03_RS27430 Protein ID WP_004181778.1
Coordinates 74803..75087 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag FGF03_RS27435 Protein ID WP_025368601.1
Coordinates 75077..75325 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGF03_RS27400 70181..71307 + 1127 Protein_69 conjugal transfer protein TraG N-terminal domain-containing protein -
FGF03_RS27405 71373..72599 - 1227 WP_025368604.1 transposase -
FGF03_RS27410 72636..73061 + 426 WP_040120489.1 IS200/IS605 family transposase -
FGF03_RS27420 73347..74573 - 1227 WP_025368602.1 transposase -
FGF03_RS27430 74803..75087 - 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGF03_RS27435 75077..75325 - 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FGF03_RS27440 75616..77415 + 1800 WP_025368600.1 ATP-dependent helicase -
FGF03_RS27445 77749..78735 + 987 WP_025368599.1 hypothetical protein -
FGF03_RS27450 78880..79233 + 354 WP_004181774.1 hypothetical protein -
FGF03_RS27455 79295..80116 + 822 WP_004026535.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / sul2 / armA / msr(E) / mph(E) / dfrA5 / qacE / sul1 / mph(A) rmpA2 / iutA / iucD / iucC / iucB / iucA / iucA / rmpA 1..339117 339117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T126922 WP_004181778.1 NZ_CP040726:c75087-74803 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T126922 NZ_CP040726:c75087-74803 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTCCATGGACGCAAAGACCAGTACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTAACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTGACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT126922 WP_025368601.1 NZ_CP040726:c75325-75077 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT126922 NZ_CP040726:c75325-75077 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACCTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCATATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References