126920

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 16132..16597 Replicon plasmid pKpvST147B_3
Accession NZ_CP040725
Organism Klebsiella pneumoniae strain KpvST147B_SE1_1_NDM

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag FGF03_RS26905 Protein ID WP_001230707.1
Coordinates 16132..16383 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag FGF03_RS26910 Protein ID WP_000801440.1
Coordinates 16370..16597 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGF03_RS26880 11614..12141 - 528 WP_000577043.1 DUF2726 domain-containing protein -
FGF03_RS26885 12276..12680 - 405 WP_012421203.1 hypothetical protein -
FGF03_RS26890 12693..13558 - 866 Protein_18 replication initiation protein -
FGF03_RS26895 14973..15488 + 516 WP_001025395.1 J domain-containing protein -
FGF03_RS26900 15593..16135 + 543 WP_001083906.1 hypothetical protein -
FGF03_RS26905 16132..16383 + 252 WP_001230707.1 hypothetical protein Toxin
FGF03_RS26910 16370..16597 + 228 WP_000801440.1 hypothetical protein Antitoxin
FGF03_RS26920 17053..17352 + 300 WP_000650309.1 hypothetical protein -
FGF03_RS26925 17443..17793 + 351 WP_000854259.1 hypothetical protein -
FGF03_RS26930 18098..18346 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
FGF03_RS26935 18343..18690 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
FGF03_RS26945 19051..19554 + 504 WP_000781813.1 hypothetical protein -
FGF03_RS26950 19558..20787 + 1230 WP_113439821.1 relaxase/mobilization nuclease domain-containing protein -
FGF03_RS26955 20864..21157 + 294 WP_000134733.1 LuxR family transcriptional regulator -
FGF03_RS26960 21154..21369 + 216 WP_000760375.1 EexN family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..31607 31607


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T126920 WP_001230707.1 NZ_CP040725:16132-16383 [Klebsiella pneumoniae]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T126920 NZ_CP040725:16132-16383 [Klebsiella pneumoniae]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT126920 WP_000801440.1 NZ_CP040725:16370-16597 [Klebsiella pneumoniae]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT126920 NZ_CP040725:16370-16597 [Klebsiella pneumoniae]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References