Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 5073167..5073666 Replicon chromosome
Accession NZ_CP040719
Organism Rhodococcus pyridinivorans strain YF3

Toxin (Protein)


Gene name relE Uniprot ID V9XF56
Locus tag FGO65_RS23500 Protein ID WP_024102500.1
Coordinates 5073167..5073421 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H0JMW3
Locus tag FGO65_RS23505 Protein ID WP_006550855.1
Coordinates 5073418..5073666 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGO65_RS23470 5068602..5069771 - 1170 WP_064256074.1 acyl-CoA dehydrogenase family protein -
FGO65_RS23475 5069874..5070500 + 627 WP_006550849.1 TetR family transcriptional regulator -
FGO65_RS23480 5070658..5070870 - 213 WP_024102496.1 transposase -
FGO65_RS23485 5070877..5071065 - 189 WP_138845190.1 hypothetical protein -
FGO65_RS23490 5071432..5072388 - 957 WP_019290518.1 Lsr2 family protein -
FGO65_RS28625 5072545..5073066 + 522 WP_175428047.1 hypothetical protein -
FGO65_RS23500 5073167..5073421 - 255 WP_024102500.1 Txe/YoeB family addiction module toxin Toxin
FGO65_RS23505 5073418..5073666 - 249 WP_006550855.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FGO65_RS23510 5073702..5074031 + 330 WP_138845192.1 hypothetical protein -
FGO65_RS23515 5074498..5075292 + 795 WP_138845193.1 LLM class F420-dependent oxidoreductase -
FGO65_RS23520 5075353..5076603 + 1251 WP_138845195.1 alpha/beta fold hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10077.42 Da        Isoelectric Point: 8.0410

>T126900 WP_024102500.1 NZ_CP040719:c5073421-5073167 [Rhodococcus pyridinivorans]
VNITFTDEAWDDYQFWISTDRKQLKRVNELIRDCQRDPYSGIGKPERLRHALSGLWSRRIDKEHRLVYEVIDGALVIIAA
RYHY

Download         Length: 255 bp

>T126900 NZ_CP040719:c5073421-5073167 [Rhodococcus pyridinivorans]
GTGAACATCACCTTCACCGACGAAGCCTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAACAGCTCAAGCGTGT
CAACGAGCTGATCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGACATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.59 Da        Isoelectric Point: 5.8315

>AT126900 WP_006550855.1 NZ_CP040719:c5073666-5073418 [Rhodococcus pyridinivorans]
MAAITATEARKNFFPLLEQVNKDHTPVEIVSKRGNAVLMSKDDYDAMLETSYLMQSPANARRLLASMQRARGGEYTEREL
IE

Download         Length: 249 bp

>AT126900 NZ_CP040719:c5073666-5073418 [Rhodococcus pyridinivorans]
ATGGCTGCCATCACTGCTACCGAAGCGAGAAAAAACTTCTTTCCGCTGCTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCTCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAATACACCGAAAGGGAACTC
ATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M2XPP3

Antitoxin

Source ID Structure
AlphaFold DB H0JMW3

References