126899

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4854678..4855219 Replicon chromosome
Accession NZ_CP040719
Organism Rhodococcus pyridinivorans strain YF3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FGO65_RS22375 Protein ID WP_138845823.1
Coordinates 4854678..4854977 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FGO65_RS22380 Protein ID WP_138844995.1
Coordinates 4854977..4855219 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGO65_RS22345 4850332..4851147 + 816 WP_138844991.1 SDR family oxidoreductase -
FGO65_RS22350 4851305..4852045 + 741 WP_138844993.1 FadR family transcriptional regulator -
FGO65_RS22355 4852313..4852673 - 361 Protein_4391 protein kinase -
FGO65_RS22360 4852776..4853618 - 843 Protein_4392 hypothetical protein -
FGO65_RS22365 4853614..4853910 + 297 Protein_4393 hypothetical protein -
FGO65_RS22370 4853932..4854300 + 369 WP_138845821.1 dihydrofolate reductase family protein -
FGO65_RS22375 4854678..4854977 - 300 WP_138845823.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FGO65_RS22380 4854977..4855219 - 243 WP_138844995.1 antitoxin Antitoxin
FGO65_RS22385 4855663..4856577 + 915 WP_138844997.1 LLM class flavin-dependent oxidoreductase -
FGO65_RS22390 4857178..4857729 - 552 WP_138844999.1 TetR/AcrR family transcriptional regulator -
FGO65_RS22395 4857904..4858419 + 516 WP_138845825.1 thioesterase family protein -
FGO65_RS22400 4858911..4859714 + 804 WP_006941794.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10529.25 Da        Isoelectric Point: 8.0583

>T126899 WP_138845823.1 NZ_CP040719:c4854977-4854678 [Rhodococcus pyridinivorans]
MRPIHAAKLDKTRPVLVLTRELVRPHLGRVTVAPITGTVRGLSTEVPVGPANGLEKDSVVSCDNIVTIPVSALGRSLGFF
FPAQEAALSEAIRAAFDLE

Download         Length: 300 bp

>T126899 NZ_CP040719:c4854977-4854678 [Rhodococcus pyridinivorans]
ATGCGGCCGATTCACGCCGCGAAGCTGGACAAGACGCGGCCGGTGTTGGTGTTGACCCGCGAGTTGGTGCGTCCGCACCT
GGGCAGGGTGACGGTGGCGCCGATCACCGGCACCGTGCGGGGGTTGTCGACAGAGGTGCCGGTGGGCCCGGCGAACGGAT
TGGAGAAGGATTCGGTGGTCAGTTGCGACAACATCGTCACCATTCCGGTGTCGGCGTTGGGGCGCAGTCTCGGGTTTTTC
TTTCCGGCGCAGGAAGCGGCGCTGTCCGAGGCGATTCGGGCCGCGTTCGACCTCGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9031.14 Da        Isoelectric Point: 4.9060

>AT126899 WP_138844995.1 NZ_CP040719:c4855219-4854977 [Rhodococcus pyridinivorans]
MSTQIAVRLPDEIVAFVDEEVREHRAPSRAALVLRALERERRRRIAARDVEILSRARGEADPDEFDGLARYAAGLSSDLE

Download         Length: 243 bp

>AT126899 NZ_CP040719:c4855219-4854977 [Rhodococcus pyridinivorans]
ATGAGTACGCAGATTGCGGTGCGCTTGCCGGATGAGATTGTGGCTTTCGTCGATGAGGAGGTGCGGGAGCATCGGGCTCC
CAGTCGTGCGGCGCTGGTGTTGCGGGCGCTCGAACGGGAGCGGCGTCGGCGGATCGCCGCCCGCGATGTCGAGATTCTGT
CCCGGGCTCGCGGTGAAGCGGATCCGGACGAGTTCGATGGGCTCGCACGATATGCCGCAGGCCTGTCGAGCGATCTCGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References