126896

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 97541..99100 Replicon plasmid pHX3
Accession NZ_CP040718
Organism Aeromonas veronii strain HX3

Toxin (Protein)


Gene name hipA Uniprot ID A0A806XZ83
Locus tag FGM04_RS21830 Protein ID WP_047235025.1
Coordinates 97541..98845 (-) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A189PGR7
Locus tag FGM04_RS21835 Protein ID WP_011899353.1
Coordinates 98849..99100 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGM04_RS21815 94884..95198 - 315 WP_047235023.1 hypothetical protein -
FGM04_RS21820 95203..96819 - 1617 WP_157162470.1 PAAR domain-containing protein -
FGM04_RS21825 97042..97536 - 495 WP_059296301.1 hypothetical protein -
FGM04_RS21830 97541..98845 - 1305 WP_047235025.1 type II toxin-antitoxin system HipA family toxin Toxin
FGM04_RS21835 98849..99100 - 252 WP_011899353.1 XRE family transcriptional regulator Antitoxin
FGM04_RS21840 99316..100320 - 1005 WP_047235026.1 tyrosine-type recombinase/integrase -
FGM04_RS21845 100323..100853 - 531 WP_047235027.1 hypothetical protein -
FGM04_RS21850 101201..101842 + 642 WP_157162471.1 hypothetical protein -
FGM04_RS21855 101839..102684 + 846 WP_080962355.1 hypothetical protein -
FGM04_RS21860 103169..103717 + 549 WP_047235029.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..158215 158215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(7-67)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 48087.16 Da        Isoelectric Point: 6.6364

>T126896 WP_047235025.1 NZ_CP040718:c98845-97541 [Aeromonas veronii]
MRAQQLIVAMNGEVVGTLYRAGNGAMSFQYTPEWVAEPGSRPLSLSLPLGHSRIRGSEVFNFFSNLLPDSEAIIARMQAR
FHVETAHPFDLLASVGRDCVGAIQLYPPGIDIPPVTETLAEPLEDAQIEQLLEGYQVAPLGMAEDVDFRISIAGAQEKTA
LLWHQGRWQRPQGSTPTSHIFKLPIGRIVQNNIDLRDSCENEWLCLRIAKAFGFDVANADLAAFGQKRVLIVERFDRRWS
RNGEWLLRLPQEDFCQAMGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNYSIFIEP
ASSFRMTPIYDVMSAFPIFESGGIAAQKAKMAMALQGKNKQYHFAMIQPRHFISTAAHVGFSPDRATRLMHEMAADTESV
ISAVTAELPADFPEHISNAIFQGLSSQAARIMRG

Download         Length: 1305 bp

>T126896 NZ_CP040718:c98845-97541 [Aeromonas veronii]
ATGAGAGCGCAGCAGCTGATAGTGGCAATGAACGGCGAGGTTGTGGGCACATTGTACCGAGCTGGCAACGGAGCCATGTC
ATTCCAATACACGCCGGAATGGGTCGCAGAACCAGGTTCTCGTCCGCTATCCCTCTCACTACCTCTGGGCCATAGCCGGA
TTAGAGGAAGTGAAGTCTTCAATTTTTTTAGCAACCTTCTGCCCGACTCCGAGGCGATCATTGCTAGGATGCAGGCCCGG
TTTCACGTTGAGACAGCACACCCCTTTGATCTGTTGGCTAGTGTCGGCCGAGATTGTGTTGGCGCTATCCAACTCTACCC
GCCCGGTATCGATATCCCTCCTGTCACGGAGACGCTTGCAGAGCCACTGGAAGATGCACAGATTGAGCAGTTGCTGGAAG
GCTATCAGGTGGCACCACTTGGTATGGCTGAGGATGTAGACTTTCGGATCTCGATTGCCGGTGCCCAAGAAAAGACGGCA
TTGCTTTGGCACCAAGGGCGCTGGCAGCGACCGCAGGGCAGCACCCCGACAAGTCATATCTTCAAGCTTCCCATCGGTCG
GATCGTACAAAACAACATCGACCTCCGAGACAGTTGCGAGAATGAATGGCTCTGCCTGCGGATCGCAAAGGCATTTGGCT
TTGACGTTGCCAATGCCGACTTGGCCGCATTTGGCCAAAAGCGTGTGCTGATCGTAGAGCGGTTCGATAGACGTTGGTCG
AGAAACGGTGAATGGTTGTTGCGGTTGCCTCAGGAAGATTTTTGCCAGGCGATGGGGATCGCCCCGGCTCTGAAATACGA
GTCCCATGGTGGCCCCGGCATTGCTGATGCTATGAAGTTGTTGTTGGGTTCCCGGCTAGCAGCCAAGGATAGAGAACAGT
TCTTCAAATCGCAGATCCTGTTCTGGATGTTGGCGGCGATCGATGGGCACGGCAAGAACTACAGCATCTTCATCGAGCCT
GCGTCGTCGTTCAGGATGACCCCCATCTATGATGTCATGTCAGCCTTTCCGATCTTCGAAAGCGGTGGCATTGCAGCTCA
AAAGGCCAAAATGGCGATGGCACTCCAAGGGAAAAATAAGCAGTACCACTTTGCAATGATACAGCCGCGTCACTTCATCA
GTACCGCTGCTCATGTGGGTTTTTCACCGGATAGAGCTACTCGACTTATGCACGAGATGGCTGCTGACACCGAATCGGTG
ATCTCGGCCGTAACTGCTGAGTTGCCAGCCGATTTCCCTGAGCACATCAGCAATGCCATTTTCCAAGGGCTATCCAGCCA
GGCTGCAAGGATTATGAGGGGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9290.61 Da        Isoelectric Point: 7.2047

>AT126896 WP_011899353.1 NZ_CP040718:c99100-98849 [Aeromonas veronii]
MKVTSPASLASAIRDHRKVSKLTQKDAAALVGIKQATVSDFENRPESTKLETLFKILAALDLELHVVKRGSTLDEEQAWD
REW

Download         Length: 252 bp

>AT126896 NZ_CP040718:c99100-98849 [Aeromonas veronii]
ATGAAGGTTACATCTCCAGCCTCTCTGGCTTCTGCTATCCGCGACCATCGCAAGGTCAGTAAACTGACGCAGAAAGATGC
TGCGGCATTGGTTGGGATTAAGCAGGCGACAGTCTCAGATTTTGAGAACCGGCCTGAGTCTACCAAGCTGGAGACGCTAT
TCAAGATCCTTGCTGCACTGGATCTGGAGCTTCATGTGGTTAAGCGGGGCTCTACCCTGGATGAGGAGCAAGCTTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806XZ83

Antitoxin

Source ID Structure
AlphaFold DB A0A189PGR7

References