Detailed information of TA system TA126895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2811002..2812566
• Replicon: chromosome
• Accession: NZ_CP040717
• Organism: Aeromonas veronii strain HX3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: FGM04_RS12950
• Protein ID: WP_157161631.1
• Coordinates: 2811256..2812566 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: FGM04_RS12945
• Protein ID: WP_101323164.1
• Coordinates: 2811002..2811256 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FGM04_RS12930	2808357..2808980	-	624	WP_157161628.1	recombinase family protein	-
FGM04_RS12935	2809967..2810401	+	435	WP_157161629.1	nucleotidyltransferase domain-containing protein	-
FGM04_RS12940	2810404..2810832	+	429	WP_157161630.1	DUF86 domain-containing protein	-
FGM04_RS12945	2811002..2811256	+	255	WP_101323164.1	helix-turn-helix domain-containing protein	Antitoxin
FGM04_RS12950	2811256..2812566	+	1311	WP_157161631.1	type II toxin-antitoxin system HipA family toxin	Toxin
FGM04_RS12955	2812633..2813271	-	639	Protein_2514	IS5 family transposase	-
FGM04_RS12960	2813358..2814386	+	1029	WP_157160634.1	IS110 family transposase	-
FGM04_RS12965	2814682..2814960	-	279	Protein_2516	transposase	-
FGM04_RS12970	2815438..2816343	-	906	WP_157161632.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2801497..2821763	20266
	-	inside	IScluster/Tn	-	-	2806674..2814960	8286

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49068.16 Da
• Isoelectric Point: 6.6563

>T126895 WP_157161631.1 NZ_CP040717:2811256-2812566 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQSGCRPISLSMPLRHQVYRGDEAYNFFDNLLPDNPEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGNAVPDVRRIDYKTLSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGSWCLPLNATPTTHIIKLPIGKIESHSYSIYLSQSVENEYICALIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMTILLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGRGLHPRDATLAMGLTATKGKKYAIEQIFPRHFYQTAKAVGFEKVQMEMILNEMASSL
DEVISAVRQQLPDTFPAQIADSILDGLSTRAQRLTR

Nucleotide

• Length: 1311 bp

>T126895 NZ_CP040717:2811256-2812566 [Aeromonas veronii]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGTGCCCATCAGTTTCA
GTACCATGAGTCATGGCTGGCACAGTCAGGTTGCCGTCCCATCTCACTCTCCATGCCATTGCGCCATCAGGTCTACCGGG
GCGATGAAGCCTATAACTTCTTTGACAATCTGCTGCCAGATAATCCGGAGGTGAGGAACCGGGTTGTAGCACGCTATCAA
GCGGCATCAACCCAGCCCTTTGATCTGCTCAGCTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GAACGCTGTTCCAGATGTCCGACGAATCGACTATAAGACCCTTTCCGATGACGAGCTGGAACAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGCATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCCATCGCCGGGGCACAAGAAAAGACAGCG
CTGCTCTATCTCGATGGCAGTTGGTGCTTGCCACTCAATGCAACACCGACAACCCACATTATCAAACTCCCCATCGGCAA
GATTGAAAGCCACTCCTACTCGATATACCTCTCCCAGAGCGTAGAAAACGAATATATCTGCGCTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTCGGCCAAGTCAAAGCACTTGCTGTGGAACGCTTCGACAGACGT
TACGCTGCAGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
GTACGAGAGCCATGGAGGCCCAGGGATCACTGACATCATGACAATCCTGCTAGGCTCTGCTACGCCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTGCTGTTCTGGTTACTGGCTGCAACCGATGGCCATGCCAAGAATTTCTCGGTGTTTATC
GAACCGGAAGGGCGTTTTCGCCTGACACCATTTTACGACATCCTCTCCATGTATCCCGCGTTTGGTGGTCGAGGTCTACA
CCCACGCGATGCAACGCTGGCCATGGGCCTGACCGCGACCAAGGGCAAGAAATATGCTATAGAGCAGATTTTTCCTCGCC
ATTTCTATCAGACTGCCAAAGCGGTTGGATTTGAAAAGGTGCAAATGGAAATGATCCTAAACGAAATGGCAAGTAGTCTG
GATGAAGTAATCTCGGCCGTCCGTCAGCAGTTACCAGATACATTTCCCGCCCAGATTGCGGACTCGATTCTGGATGGGCT
CAGCACCAGAGCGCAGCGTTTAACTCGGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9323.64 Da
• Isoelectric Point: 7.9834

>AT126895 WP_101323164.1 NZ_CP040717:2811002-2811256 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPTSGW
KEEW

Nucleotide

• Length: 255 bp

>AT126895 NZ_CP040717:2811002-2811256 [Aeromonas veronii]
ATGAAAGTAACCAGCGCCAAGCAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCGCAAAAGCTTTCCCAGGGTAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACTGTATCCAGCTTCGAGCTCAACCCTGAGTCCACCAAGCTGGAGACCCTGT
TCAAAATCCTCGCAGCACTCGAGTTGTCACTGGATATCAAACCCCGCAATGAGTCCTCCGATAGCCCTACATCAGGCTGG
AAGGAGGAGTGGTAA