Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4996509..4997163 Replicon chromosome
Accession NZ_CP040711
Organism Klebsiella pneumoniae strain 16HN-35

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag FGL96_RS24490 Protein ID WP_004144731.1
Coordinates 4996509..4996916 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FGL96_RS24495 Protein ID WP_002916312.1
Coordinates 4996897..4997163 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL96_RS24470 (FGL96_24630) 4992509..4994242 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
FGL96_RS24475 (FGL96_24635) 4994248..4994961 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FGL96_RS24480 (FGL96_24640) 4994984..4995880 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FGL96_RS24485 (FGL96_24645) 4995981..4996502 + 522 WP_002916308.1 flavodoxin FldB -
FGL96_RS24490 (FGL96_24650) 4996509..4996916 - 408 WP_004144731.1 protein YgfX Toxin
FGL96_RS24495 (FGL96_24655) 4996897..4997163 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FGL96_RS24500 (FGL96_24660) 4997409..4998392 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FGL96_RS24505 (FGL96_24665) 4998543..4999202 - 660 WP_002916317.1 hemolysin III family protein -
FGL96_RS24510 (FGL96_24670) 4999366..4999677 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FGL96_RS24515 (FGL96_24675) 4999727..5000455 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FGL96_RS24520 (FGL96_24680) 5000574..5002007 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T126883 WP_004144731.1 NZ_CP040711:c4996916-4996509 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T126883 NZ_CP040711:c4996916-4996509 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT126883 WP_002916312.1 NZ_CP040711:c4997163-4996897 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT126883 NZ_CP040711:c4997163-4996897 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References