Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 985216..985732 Replicon chromosome
Accession NZ_CP040711
Organism Klebsiella pneumoniae strain 16HN-35

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FGL96_RS04655 Protein ID WP_002886902.1
Coordinates 985448..985732 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FGL96_RS04650 Protein ID WP_002886901.1
Coordinates 985216..985458 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL96_RS04635 (FGL96_04690) 981245..981985 + 741 WP_002886899.1 KDGP aldolase family protein -
FGL96_RS04640 (FGL96_04695) 982051..983205 + 1155 WP_002886900.1 lactonase family protein -
FGL96_RS04645 (FGL96_04700) 983228..985138 + 1911 WP_004152270.1 PRD domain-containing protein -
FGL96_RS04650 (FGL96_04705) 985216..985458 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGL96_RS04655 (FGL96_04710) 985448..985732 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL96_RS04660 (FGL96_04715) 985736..986200 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FGL96_RS04665 (FGL96_04720) 986441..988579 - 2139 WP_202176189.1 anaerobic ribonucleoside-triphosphate reductase -
FGL96_RS04670 (FGL96_04725) 988936..989679 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FGL96_RS04675 989682..989855 - 174 WP_002886906.1 hypothetical protein -
FGL96_RS04680 (FGL96_04730) 989940..990248 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T126871 WP_002886902.1 NZ_CP040711:985448-985732 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T126871 NZ_CP040711:985448-985732 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT126871 WP_002886901.1 NZ_CP040711:985216-985458 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT126871 NZ_CP040711:985216-985458 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References