Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 64290..64809 Replicon plasmid p2
Accession NZ_CP040708
Organism Enterococcus faecium strain HOU503

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag FGF98_RS15540 Protein ID WP_000588503.1
Coordinates 64552..64809 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag FGF98_RS15535 Protein ID WP_000388479.1
Coordinates 64290..64559 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGF98_RS15500 59505..60068 - 564 WP_000017403.1 recombinase family protein -
FGF98_RS15505 60711..61664 + 954 WP_000222572.1 IS30 family transposase -
FGF98_RS15510 61642..62232 + 591 Protein_76 RNA-directed DNA polymerase -
FGF98_RS15515 62277..62957 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
FGF98_RS15520 63033..63599 + 567 Protein_78 hypothetical protein -
FGF98_RS15530 63980..64159 + 180 WP_001120991.1 hypothetical protein -
FGF98_RS15535 64290..64559 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FGF98_RS15540 64552..64809 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
FGF98_RS15545 65447..66271 + 825 WP_001809248.1 hypothetical protein -
FGF98_RS15550 66436..67050 - 615 WP_001261742.1 recombinase family protein -
FGF98_RS15555 67500..68825 + 1326 WP_000969590.1 Y-family DNA polymerase -
FGF98_RS15560 68818..69168 + 351 WP_000568378.1 hypothetical protein -
FGF98_RS15565 69165..69344 + 180 WP_001021554.1 hypothetical protein -
FGF98_RS15570 69480..69770 + 291 WP_000026576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid VanHAX / erm(B) / ant(6)-Ia / aph(3')-III - 1..71214 71214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T126865 WP_000588503.1 NZ_CP040708:64552-64809 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T126865 NZ_CP040708:64552-64809 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT126865 WP_000388479.1 NZ_CP040708:64290-64559 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT126865 NZ_CP040708:64290-64559 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References