Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Txe-YefM |
| Location | 3770626..3771155 | Replicon | chromosome |
| Accession | NZ_CP040693 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0145 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | G0TI95 |
| Locus tag | FF953_RS17735 | Protein ID | WP_003417760.1 |
| Coordinates | 3770898..3771155 (+) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | G0TI94 |
| Locus tag | FF953_RS17730 | Protein ID | WP_003417757.1 |
| Coordinates | 3770626..3770901 (+) | Length | 92 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF953_RS17695 (FF953_18360) | 3767199..3767888 | - | 690 | WP_003917774.1 | BBE domain-containing protein | - |
| FF953_RS17700 (FF953_18365) | 3768075..3768446 | - | 372 | WP_003417739.1 | FAD-binding protein | - |
| FF953_RS17705 | 3768344..3768562 | - | 219 | WP_157132559.1 | hypothetical protein | - |
| FF953_RS17710 (FF953_18375) | 3768589..3768849 | - | 261 | WP_003417741.1 | hypothetical protein | - |
| FF953_RS17715 (FF953_18380) | 3768964..3769353 | + | 390 | WP_003417745.1 | DUF732 domain-containing protein | - |
| FF953_RS17720 (FF953_18385) | 3769367..3769660 | - | 294 | WP_003417749.1 | DUF3017 domain-containing protein | - |
| FF953_RS17725 (FF953_18390) | 3769657..3770502 | - | 846 | WP_003417751.1 | bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase | - |
| FF953_RS17730 (FF953_18395) | 3770626..3770901 | + | 276 | WP_003417757.1 | type II toxin-antitoxin system antitoxin RelJ | Antitoxin |
| FF953_RS17735 (FF953_18400) | 3770898..3771155 | + | 258 | WP_003417760.1 | Txe/YoeB family addiction module toxin | Toxin |
| FF953_RS17740 (FF953_18405) | 3771197..3772387 | + | 1191 | WP_003900033.1 | NADH:flavin oxidoreductase | - |
| FF953_RS17745 (FF953_18410) | 3772504..3772872 | + | 369 | WP_003417765.1 | FHA domain-containing protein | - |
| FF953_RS17750 (FF953_18415) | 3772869..3773420 | - | 552 | WP_003417767.1 | pentapeptide repeat protein MfpA | - |
| FF953_RS17755 (FF953_18420) | 3773427..3774008 | - | 582 | WP_003417769.1 | ATP/GTP-binding protein | - |
| FF953_RS17760 (FF953_18425) | 3773989..3774357 | - | 369 | WP_003417772.1 | DUF742 domain-containing protein | - |
| FF953_RS17765 (FF953_18430) | 3774335..3774727 | - | 393 | WP_003417776.1 | serine protease inhibitor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10070.30 Da Isoelectric Point: 6.4693
>T126856 WP_003417760.1 NZ_CP040693:3770898-3771155 [Mycobacterium tuberculosis complex sp. N0145]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY
Download Length: 258 bp
>T126856 NZ_CP040693:3770898-3771155 [Mycobacterium tuberculosis complex sp. N0145]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA
Antitoxin
Download Length: 92 a.a. Molecular weight: 10194.35 Da Isoelectric Point: 4.6652
>AT126856 WP_003417757.1 NZ_CP040693:3770626-3770901 [Mycobacterium tuberculosis complex sp. N0145]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE
Download Length: 276 bp
>AT126856 NZ_CP040693:3770626-3770901 [Mycobacterium tuberculosis complex sp. N0145]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|