Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
| Location | 3700549..3701223 | Replicon | chromosome |
| Accession | NZ_CP040693 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0145 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF52 |
| Locus tag | FF953_RS17515 | Protein ID | WP_003417282.1 |
| Coordinates | 3700549..3700977 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TI59 |
| Locus tag | FF953_RS17520 | Protein ID | WP_003417286.1 |
| Coordinates | 3700981..3701223 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF953_RS17490 (FF953_18135) | 3696371..3696772 | - | 402 | WP_003417264.1 | cytidine deaminase | - |
| FF953_RS17495 (FF953_18140) | 3697009..3697347 | + | 339 | WP_003417267.1 | succinate dehydrogenase, cytochrome b556 subunit | - |
| FF953_RS17500 (FF953_18145) | 3697344..3697778 | + | 435 | WP_003902441.1 | succinate dehydrogenase hydrophobic membrane anchor subunit | - |
| FF953_RS17505 (FF953_18150) | 3697907..3699679 | + | 1773 | WP_003417273.1 | succinate dehydrogenase flavoprotein subunit | - |
| FF953_RS17510 (FF953_18155) | 3699679..3700470 | + | 792 | WP_003417279.1 | succinate dehydrogenase iron-sulfur subunit | - |
| FF953_RS17515 (FF953_18160) | 3700549..3700977 | - | 429 | WP_003417282.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| FF953_RS17520 (FF953_18165) | 3700981..3701223 | - | 243 | WP_003417286.1 | CopG family transcriptional regulator | Antitoxin |
| FF953_RS17525 (FF953_18170) | 3701345..3701959 | - | 615 | WP_003417288.1 | class I SAM-dependent methyltransferase | - |
| FF953_RS17530 (FF953_18175) | 3701956..3702621 | - | 666 | WP_003417290.1 | molybdopterin converting factor subunit 1 | - |
| FF953_RS17535 (FF953_18180) | 3702622..3703155 | - | 534 | WP_003417293.1 | cyclic pyranopterin monophosphate synthase MoaC | - |
| FF953_RS17540 (FF953_18185) | 3703152..3703526 | - | 375 | WP_003417295.1 | 4a-hydroxytetrahydrobiopterin dehydratase | - |
| FF953_RS17545 (FF953_18190) | 3703623..3704759 | - | 1137 | WP_003417297.1 | GTP 3',8-cyclase MoaA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15834.16 Da Isoelectric Point: 8.5471
>T126855 WP_003417282.1 NZ_CP040693:c3700977-3700549 [Mycobacterium tuberculosis complex sp. N0145]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL
Download Length: 429 bp
>T126855 NZ_CP040693:c3700977-3700549 [Mycobacterium tuberculosis complex sp. N0145]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8849.86 Da Isoelectric Point: 5.1007
>AT126855 WP_003417286.1 NZ_CP040693:c3701223-3700981 [Mycobacterium tuberculosis complex sp. N0145]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV
Download Length: 243 bp
>AT126855 NZ_CP040693:c3701223-3700981 [Mycobacterium tuberculosis complex sp. N0145]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4FBL0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TI59 |