Detailed information of TA system TA126852

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3165877..3166425
• Replicon: chromosome
• Accession: NZ_CP040693
• Organism: Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TFG5
• Locus tag: FF953_RS15095
• Protein ID: WP_003414602.1
• Coordinates: 3166162..3166425 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: O33347
• Locus tag: FF953_RS15090
• Protein ID: WP_003414599.1
• Coordinates: 3165877..3166158 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF953_RS15065 (FF953_15595)	3161501..3162358	-	858	WP_003899513.1	type I methionyl aminopeptidase	-
FF953_RS15070 (FF953_15600)	3162400..3162984	-	585	WP_003414585.1	DUF1707 domain-containing protein	-
FF953_RS15075 (FF953_15605)	3163087..3163335	+	249	WP_003913411.1	antitoxin VapB23	-
FF953_RS15080 (FF953_15610)	3163332..3163712	+	381	WP_003414592.1	type II toxin-antitoxin system VapC family toxin	-
FF953_RS15085 (FF953_15615)	3163794..3165605	-	1812	WP_003414596.1	penicillin-binding protein	-
FF953_RS15090 (FF953_15620)	3165877..3166158	+	282	WP_003414599.1	type II toxin-antitoxin system antitoxin RelF	Antitoxin
FF953_RS15095 (FF953_15625)	3166162..3166425	+	264	WP_003414602.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FF953_RS15100 (FF953_15630)	3166798..3167652	-	855	WP_003899516.1	GNAT family N-acetyltransferase	-
FF953_RS15105 (FF953_15635)	3167708..3168871	-	1164	WP_003899517.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
FF953_RS15110 (FF953_15640)	3168888..3170102	-	1215	WP_003414610.1	zinc metalloprotease Rip	-
FF953_RS15115 (FF953_15645)	3170110..3171351	-	1242	WP_003414613.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10204.82 Da
• Isoelectric Point: 11.5078

>T126852 WP_003414602.1 NZ_CP040693:3166162-3166425 [Mycobacterium tuberculosis complex sp. N0145]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Nucleotide

• Length: 264 bp

>T126852 NZ_CP040693:3166162-3166425 [Mycobacterium tuberculosis complex sp. N0145]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10183.40 Da
• Isoelectric Point: 4.3440

>AT126852 WP_003414599.1 NZ_CP040693:3165877-3166158 [Mycobacterium tuberculosis complex sp. N0145]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Nucleotide

• Length: 282 bp

>AT126852 NZ_CP040693:3165877-3166158 [Mycobacterium tuberculosis complex sp. N0145]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Structures

Toxin

• PDB: 3G5O

Antitoxin

• PDB: 3G5O
• AlphaFold DB: A0A7U4BWP8