Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | unclassified/- |
| Location | 2970931..2971579 | Replicon | chromosome |
| Accession | NZ_CP040693 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0145 | ||
Toxin (Protein)
| Gene name | novel[antitoxin] | Uniprot ID | P9WJ12 |
| Locus tag | FF953_RS14005 | Protein ID | WP_003899414.1 |
| Coordinates | 2970931..2971254 (-) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | novel[toxin] | Uniprot ID | P9WJ10 |
| Locus tag | FF953_RS14010 | Protein ID | WP_003899415.1 |
| Coordinates | 2971334..2971579 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF953_RS13975 (FF953_14475) | 2966254..2967252 | + | 999 | WP_003900538.1 | tyrosine-type recombinase/integrase | - |
| FF953_RS13980 (FF953_14480) | 2967266..2967730 | + | 465 | WP_003900539.1 | ParB N-terminal domain-containing protein | - |
| FF953_RS13985 (FF953_14485) | 2967718..2967969 | + | 252 | WP_003908028.1 | hypothetical protein | - |
| FF953_RS13990 (FF953_14490) | 2968140..2969579 | - | 1440 | WP_003901443.1 | phage major capsid protein | - |
| FF953_RS13995 (FF953_14495) | 2969587..2970120 | - | 534 | WP_003899412.1 | HK97 family phage prohead protease | - |
| FF953_RS14000 (FF953_14500) | 2970273..2970764 | - | 492 | WP_003900541.1 | phage terminase small subunit P27 family | - |
| FF953_RS14005 (FF953_14505) | 2970931..2971254 | - | 324 | WP_003899414.1 | type II toxin-antitoxin system toxin | Toxin |
| FF953_RS14010 (FF953_14510) | 2971334..2971579 | - | 246 | WP_003899415.1 | type II toxin-antitoxin system antitoxin | Antitoxin |
| FF953_RS14015 (FF953_14515) | 2971576..2973003 | - | 1428 | WP_003899416.1 | DUF3631 domain-containing protein | - |
| FF953_RS14020 (FF953_14520) | 2973005..2973397 | - | 393 | WP_003899417.1 | DUF2742 domain-containing protein | - |
| FF953_RS14025 (FF953_14525) | 2973394..2973654 | - | 261 | WP_003899418.1 | helix-turn-helix domain-containing protein | - |
| FF953_RS14030 (FF953_14530) | 2973671..2974033 | - | 363 | WP_003900543.1 | hypothetical protein | - |
| FF953_RS14035 (FF953_14535) | 2974036..2975163 | - | 1128 | WP_003899420.1 | site-specific integrase | - |
| FF953_RS14040 (FF953_14540) | 2975308..2975535 | - | 228 | WP_003899421.1 | hypothetical protein | - |
| FF953_RS14045 (FF953_14545) | 2975532..2975921 | - | 390 | WP_003899422.1 | hypothetical protein | - |
| FF953_RS14050 (FF953_14550) | 2975827..2976099 | + | 273 | WP_003900544.1 | hypothetical protein | - |
| FF953_RS14055 (FF953_14555) | 2976198..2976431 | + | 234 | WP_003413717.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2966254..2975163 | 8909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12359.82 Da Isoelectric Point: 8.6717
>T126846 WP_003899414.1 NZ_CP040693:c2971254-2970931 [Mycobacterium tuberculosis complex sp. N0145]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ
Download Length: 324 bp
>T126846 NZ_CP040693:c2971254-2970931 [Mycobacterium tuberculosis complex sp. N0145]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA
Antitoxin
Download Length: 82 a.a. Molecular weight: 7697.71 Da Isoelectric Point: 4.8565
>AT126846 WP_003899415.1 NZ_CP040693:c2971579-2971334 [Mycobacterium tuberculosis complex sp. N0145]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P
Download Length: 246 bp
>AT126846 NZ_CP040693:c2971579-2971334 [Mycobacterium tuberculosis complex sp. N0145]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A045IHC4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A806JR81 |