Detailed information of TA system TA126841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2849972..2850612
• Replicon: chromosome
• Accession: NZ_CP040693
• Organism: Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: FF953_RS13350
• Protein ID: WP_003412970.1
• Coordinates: 2849972..2850391 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: FF953_RS13355
• Protein ID: WP_003412975.1
• Coordinates: 2850388..2850612 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF953_RS13320 (FF953_13795)	2845562..2846284	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
FF953_RS13325 (FF953_13805)	2846801..2847023	+	223	Protein_2630	type II toxin-antitoxin system VapB family antitoxin	-
FF953_RS13330 (FF953_13810)	2847020..2847421	+	402	WP_003412963.1	PIN domain-containing protein	-
FF953_RS13335 (FF953_13815)	2847456..2848376	-	921	WP_003412965.1	restriction endonuclease	-
FF953_RS13340	2848717..2848962	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FF953_RS13345 (FF953_13820)	2849021..2849971	+	951	WP_003911916.1	ERCC4 domain-containing protein	-
FF953_RS13350 (FF953_13825)	2849972..2850391	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF953_RS13355 (FF953_13830)	2850388..2850612	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
FF953_RS13360 (FF953_13835)	2850643..2853486	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
FF953_RS13365 (FF953_13840)	2853558..2853959	-	402	WP_003412981.1	hypothetical protein	-
FF953_RS13370 (FF953_13845)	2853959..2854429	-	471	WP_003899364.1	transcription antitermination factor NusB	-
FF953_RS13375 (FF953_13850)	2854432..2854995	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T126841 WP_003412970.1 NZ_CP040693:c2850391-2849972 [Mycobacterium tuberculosis complex sp. N0145]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T126841 NZ_CP040693:c2850391-2849972 [Mycobacterium tuberculosis complex sp. N0145]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT126841 WP_003412975.1 NZ_CP040693:c2850612-2850388 [Mycobacterium tuberculosis complex sp. N0145]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT126841 NZ_CP040693:c2850612-2850388 [Mycobacterium tuberculosis complex sp. N0145]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09