Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2803793..2804445 Replicon chromosome
Accession NZ_CP040693
Organism Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)


Gene name vapC Uniprot ID A0A5R1ZCY8
Locus tag FF953_RS13155 Protein ID WP_003905869.1
Coordinates 2804020..2804445 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag FF953_RS13150 Protein ID WP_003412749.1
Coordinates 2803793..2804014 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF953_RS13135 (FF953_13580) 2802033..2802239 - 207 WP_003899347.1 hypothetical protein -
FF953_RS13140 (FF953_13585) 2802375..2802998 + 624 WP_003900858.1 TIGR00725 family protein -
FF953_RS13145 (FF953_13590) 2802988..2803740 + 753 WP_003901416.1 hypothetical protein -
FF953_RS13150 (FF953_13595) 2803793..2804014 + 222 WP_003412749.1 antitoxin Antitoxin
FF953_RS13155 (FF953_13600) 2804020..2804445 + 426 WP_003905869.1 type II toxin-antitoxin system VapC family toxin Toxin
FF953_RS13160 (FF953_13605) 2804468..2805649 - 1182 WP_003905870.1 dihydrolipoamide acetyltransferase family protein -
FF953_RS13165 (FF953_13610) 2805646..2806692 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
FF953_RS13170 (FF953_13615) 2806703..2807806 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
FF953_RS13175 (FF953_13620) 2808065..2808886 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
FF953_RS13180 (FF953_13625) 2808883..2809440 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15364.84 Da        Isoelectric Point: 9.2386

>T126840 WP_003905869.1 NZ_CP040693:2804020-2804445 [Mycobacterium tuberculosis complex sp. N0145]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRASTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T126840 NZ_CP040693:2804020-2804445 [Mycobacterium tuberculosis complex sp. N0145]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGCGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT126840 WP_003412749.1 NZ_CP040693:2803793-2804014 [Mycobacterium tuberculosis complex sp. N0145]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT126840 NZ_CP040693:2803793-2804014 [Mycobacterium tuberculosis complex sp. N0145]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R1ZCY8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References