Detailed information of TA system TA126839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 2399869..2400398
• Replicon: chromosome
• Accession: NZ_CP040693
• Organism: Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0TMR4
• Locus tag: FF953_RS11240
• Protein ID: WP_003411124.1
• Coordinates: 2399869..2400186 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: P9WJ74
• Locus tag: FF953_RS11245
• Protein ID: WP_003411127.1
• Coordinates: 2400183..2400398 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF953_RS11210 (FF953_11610)	2394890..2395966	+	1077	WP_003411110.1	hypothetical protein	-
FF953_RS11215 (FF953_11615)	2395963..2396244	+	282	WP_003411112.1	DUF5703 family protein	-
FF953_RS11220 (FF953_11620)	2396280..2397353	+	1074	WP_003901338.1	quinone-dependent dihydroorotate dehydrogenase	-
FF953_RS11225 (FF953_11625)	2397358..2397888	-	531	WP_003411119.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
FF953_RS11230 (FF953_11630)	2397936..2399282	-	1347	WP_003411121.1	M20/M25/M40 family metallo-hydrolase	-
FF953_RS11240 (FF953_11640)	2399869..2400186	-	318	WP_003411124.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FF953_RS11245 (FF953_11645)	2400183..2400398	-	216	WP_003411127.1	antitoxin ParD2	Antitoxin
FF953_RS11250 (FF953_11650)	2400653..2401711	+	1059	WP_003411129.1	phosphoribosyltransferase family protein	-
FF953_RS11255 (FF953_11655)	2401841..2402197	-	357	WP_003411130.1	hypothetical protein	-
FF953_RS11260 (FF953_11660)	2402292..2403074	-	783	WP_003411131.1	cell wall synthesis protein Wag31	-
FF953_RS11265 (FF953_11665)	2403342..2403632	-	291	WP_003900476.1	YggT family protein	-
FF953_RS11270 (FF953_11670)	2403794..2404450	-	657	WP_003411133.1	cell division protein SepF	-
FF953_RS11275 (FF953_11675)	2404512..2405291	-	780	WP_015575160.1	YggS family pyridoxal phosphate-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Conserved hypothetical protein CHP02574, addiction module (11-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12312.88 Da
• Isoelectric Point: 6.4831

>T126839 WP_003411124.1 NZ_CP040693:c2400186-2399869 [Mycobacterium tuberculosis complex sp. N0145]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Nucleotide

• Length: 318 bp

>T126839 NZ_CP040693:c2400186-2399869 [Mycobacterium tuberculosis complex sp. N0145]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7880.70 Da
• Isoelectric Point: 4.4055

>AT126839 WP_003411127.1 NZ_CP040693:c2400398-2400183 [Mycobacterium tuberculosis complex sp. N0145]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Nucleotide

• Length: 216 bp

>AT126839 NZ_CP040693:c2400398-2400183 [Mycobacterium tuberculosis complex sp. N0145]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: G0TMR4

Antitoxin

• AlphaFold DB: A0A7U4FAJ4