Detailed information of TA system TA126838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2361705..2362400
• Replicon: chromosome
• Accession: NZ_CP040693
• Organism: Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FF953_RS11030
• Protein ID: WP_003905754.1
• Coordinates: 2361705..2362139 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: FF953_RS11035
• Protein ID: WP_003410814.1
• Coordinates: 2362146..2362400 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF953_RS11020 (FF953_11420)	2357859..2360900	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
FF953_RS11025 (FF953_11425)	2360893..2361726	+	834	WP_003899172.1	SWIM zinc finger family protein	-
FF953_RS11030 (FF953_11430)	2361705..2362139	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF953_RS11035 (FF953_11435)	2362146..2362400	-	255	WP_003410814.1	antitoxin	Antitoxin
FF953_RS11040 (FF953_11440)	2362416..2362673	-	258	WP_003410816.1	hypothetical protein	-
FF953_RS11045 (FF953_11450)	2363207..2364468	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
FF953_RS11050 (FF953_11455)	2364978..2365274	+	297	WP_003410820.1	PE family protein	-
FF953_RS11055 (FF953_11460)	2365330..2366061	+	732	WP_003900467.1	PPE family protein	-
FF953_RS11060 (FF953_11465)	2366601..2367347	-	747	WP_003901330.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T126838 WP_003905754.1 NZ_CP040693:c2362139-2361705 [Mycobacterium tuberculosis complex sp. N0145]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T126838 NZ_CP040693:c2362139-2361705 [Mycobacterium tuberculosis complex sp. N0145]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT126838 WP_003410814.1 NZ_CP040693:c2362400-2362146 [Mycobacterium tuberculosis complex sp. N0145]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT126838 NZ_CP040693:c2362400-2362146 [Mycobacterium tuberculosis complex sp. N0145]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0