126834

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2225604..2226190 Replicon chromosome
Accession NZ_CP040693
Organism Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag FF953_RS10430 Protein ID WP_003410010.1
Coordinates 2225604..2225948 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag FF953_RS10435 Protein ID WP_003410014.1
Coordinates 2225942..2226190 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF953_RS10395 (FF953_10775) 2221310..2221909 + 600 WP_003910883.1 L-lysine exporter -
FF953_RS10400 (FF953_10780) 2222325..2222753 + 429 WP_003409992.1 cellulose-binding protein -
FF953_RS10405 (FF953_10785) 2222979..2223518 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FF953_RS10410 (FF953_10795) 2224038..2224598 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
FF953_RS10415 (FF953_10800) 2224595..2224936 - 342 WP_003410003.1 DUF2384 domain-containing protein -
FF953_RS10420 (FF953_10805) 2225022..2225279 + 258 WP_003410006.1 hypothetical protein -
FF953_RS10425 (FF953_10810) 2225180..2225515 - 336 WP_003410009.1 dehydrogenase -
FF953_RS10430 (FF953_10815) 2225604..2225948 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
FF953_RS10435 (FF953_10820) 2225942..2226190 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
FF953_RS10440 (FF953_10825) 2226290..2228605 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FF953_RS10445 (FF953_10830) 2228602..2228874 - 273 WP_003410017.1 DUF1490 family protein -
FF953_RS10450 (FF953_10835) 2228927..2229283 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
FF953_RS10455 (FF953_10840) 2229440..2230207 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T126834 WP_003410010.1 NZ_CP040693:c2225948-2225604 [Mycobacterium tuberculosis complex sp. N0145]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T126834 NZ_CP040693:c2225948-2225604 [Mycobacterium tuberculosis complex sp. N0145]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT126834 WP_003410014.1 NZ_CP040693:c2226190-2225942 [Mycobacterium tuberculosis complex sp. N0145]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT126834 NZ_CP040693:c2226190-2225942 [Mycobacterium tuberculosis complex sp. N0145]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References