Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2224038..2224936 Replicon chromosome
Accession NZ_CP040693
Organism Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag FF953_RS10410 Protein ID WP_003410001.1
Coordinates 2224038..2224598 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag FF953_RS10415 Protein ID WP_003410003.1
Coordinates 2224595..2224936 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF953_RS10380 (FF953_10760) 2219207..2219860 - 654 WP_003409976.1 cutinase Cfp21 -
FF953_RS10385 (FF953_10765) 2219975..2220205 + 231 WP_003409980.1 DUF167 domain-containing protein -
FF953_RS10390 (FF953_10770) 2220290..2221201 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
FF953_RS10395 (FF953_10775) 2221310..2221909 + 600 WP_003910883.1 L-lysine exporter -
FF953_RS10400 (FF953_10780) 2222325..2222753 + 429 WP_003409992.1 cellulose-binding protein -
FF953_RS10405 (FF953_10785) 2222979..2223518 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
FF953_RS10410 (FF953_10795) 2224038..2224598 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
FF953_RS10415 (FF953_10800) 2224595..2224936 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
FF953_RS10420 (FF953_10805) 2225022..2225279 + 258 WP_003410006.1 hypothetical protein -
FF953_RS10425 (FF953_10810) 2225180..2225515 - 336 WP_003410009.1 dehydrogenase -
FF953_RS10430 (FF953_10815) 2225604..2225948 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
FF953_RS10435 (FF953_10820) 2225942..2226190 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
FF953_RS10440 (FF953_10825) 2226290..2228605 - 2316 WP_003899120.1 cation transporter ATPase CptG -
FF953_RS10445 (FF953_10830) 2228602..2228874 - 273 WP_003410017.1 DUF1490 family protein -
FF953_RS10450 (FF953_10835) 2228927..2229283 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T126833 WP_003410001.1 NZ_CP040693:c2224598-2224038 [Mycobacterium tuberculosis complex sp. N0145]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T126833 NZ_CP040693:c2224598-2224038 [Mycobacterium tuberculosis complex sp. N0145]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT126833 WP_003410003.1 NZ_CP040693:c2224936-2224595 [Mycobacterium tuberculosis complex sp. N0145]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT126833 NZ_CP040693:c2224936-2224595 [Mycobacterium tuberculosis complex sp. N0145]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References