Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2190484..2191028 | Replicon | chromosome |
| Accession | NZ_CP040693 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0145 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | FF953_RS10210 | Protein ID | WP_003409896.1 |
| Coordinates | 2190484..2190780 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | FF953_RS10215 | Protein ID | WP_003409899.1 |
| Coordinates | 2190777..2191028 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF953_RS10155 (FF953_10520) | 2185517..2185867 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| FF953_RS10160 (FF953_10525) | 2185878..2186780 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| FF953_RS10165 (FF953_10530) | 2186801..2186992 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FF953_RS10170 (FF953_10535) | 2186993..2187289 | - | 297 | WP_031715189.1 | hypothetical protein | - |
| FF953_RS10175 (FF953_10540) | 2187529..2187744 | + | 216 | WP_003409878.1 | antitoxin | - |
| FF953_RS10180 (FF953_10545) | 2187741..2188052 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF953_RS10185 | 2188026..2188547 | - | 522 | WP_003904745.1 | hypothetical protein | - |
| FF953_RS10190 (FF953_10555) | 2188522..2188899 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| FF953_RS10195 (FF953_10560) | 2188941..2189390 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| FF953_RS10200 (FF953_10565) | 2189387..2189932 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FF953_RS10205 (FF953_10570) | 2189821..2190435 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FF953_RS10210 (FF953_10575) | 2190484..2190780 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FF953_RS10215 (FF953_10580) | 2190777..2191028 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| FF953_RS10220 (FF953_10585) | 2191015..2191509 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FF953_RS10225 (FF953_10590) | 2191669..2192076 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FF953_RS10230 (FF953_10595) | 2192080..2192352 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FF953_RS10235 (FF953_10600) | 2192385..2193605 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| FF953_RS10240 (FF953_10615) | 2194504..2195301 | + | 798 | WP_003899101.1 | ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T126831 WP_003409896.1 NZ_CP040693:c2190780-2190484 [Mycobacterium tuberculosis complex sp. N0145]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T126831 NZ_CP040693:c2190780-2190484 [Mycobacterium tuberculosis complex sp. N0145]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT126831 WP_003409899.1 NZ_CP040693:c2191028-2190777 [Mycobacterium tuberculosis complex sp. N0145]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT126831 NZ_CP040693:c2191028-2190777 [Mycobacterium tuberculosis complex sp. N0145]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |