Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1962038..1962498 Replicon chromosome
Accession NZ_CP040693
Organism Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag FF953_RS09150 Protein ID WP_003898996.1
Coordinates 1962250..1962498 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag FF953_RS09145 Protein ID WP_003408528.1
Coordinates 1962038..1962250 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF953_RS09130 (FF953_09440) 1958516..1959703 - 1188 WP_003898992.1 nitrate transporter NarK -
FF953_RS09135 (FF953_09445) 1959990..1960274 + 285 WP_003408522.1 DUF1876 domain-containing protein -
FF953_RS09140 (FF953_09450) 1960288..1961970 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
FF953_RS09145 (FF953_09455) 1962038..1962250 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FF953_RS09150 (FF953_09460) 1962250..1962498 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
FF953_RS09155 (FF953_09465) 1962506..1963243 + 738 WP_003898997.1 hypothetical protein -
FF953_RS09160 (FF953_09470) 1963337..1965037 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
FF953_RS09165 (FF953_09475) 1965322..1965723 - 402 WP_003408538.1 hypothetical protein -
FF953_RS09170 (FF953_09480) 1965713..1966324 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T126828 WP_003898996.1 NZ_CP040693:1962250-1962498 [Mycobacterium tuberculosis complex sp. N0145]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T126828 NZ_CP040693:1962250-1962498 [Mycobacterium tuberculosis complex sp. N0145]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT126828 WP_003408528.1 NZ_CP040693:1962038-1962250 [Mycobacterium tuberculosis complex sp. N0145]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT126828 NZ_CP040693:1962038-1962250 [Mycobacterium tuberculosis complex sp. N0145]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References