Detailed information of TA system TA126826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1770713..1771326
• Replicon: chromosome
• Accession: NZ_CP040693
• Organism: Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P64880
• Locus tag: FF953_RS08300
• Protein ID: WP_003407786.1
• Coordinates: 1770922..1771326 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E8UJ46
• Locus tag: FF953_RS08295
• Protein ID: WP_009935474.1
• Coordinates: 1770713..1770916 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF953_RS08265 (FF953_08555)	1766118..1766498	+	381	WP_003407768.1	fumarate reductase subunit C	-
FF953_RS08270 (FF953_08560)	1766495..1766872	+	378	WP_003407771.1	fumarate reductase subunit FrdD	-
FF953_RS08275 (FF953_08565)	1766940..1767548	+	609	WP_003407773.1	TetR/AcrR family transcriptional regulator	-
FF953_RS08280 (FF953_08570)	1767732..1768880	+	1149	Protein_1633	MMPL family transporter	-
FF953_RS08285 (FF953_08575)	1768890..1769336	+	447	WP_003407780.1	F420H(2)-dependent quinone reductase	-
FF953_RS08290 (FF953_08580)	1769371..1770660	+	1290	WP_003407781.1	threonine ammonia-lyase	-
FF953_RS08295 (FF953_08585)	1770713..1770916	+	204	WP_009935474.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FF953_RS08300 (FF953_08590)	1770922..1771326	+	405	WP_003407786.1	type II toxin-antitoxin system toxin ribonuclease VapC11	Toxin
FF953_RS08305 (FF953_08595)	1771343..1773085	-	1743	WP_003407788.1	malto-oligosyltrehalose trehalohydrolase	-
FF953_RS08310 (FF953_08600)	1773078..1775375	-	2298	WP_003407790.1	malto-oligosyltrehalose synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14650.76 Da
• Isoelectric Point: 5.6587

>T126826 WP_003407786.1 NZ_CP040693:1770922-1771326 [Mycobacterium tuberculosis complex sp. N0145]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Nucleotide

• Length: 405 bp

>T126826 NZ_CP040693:1770922-1771326 [Mycobacterium tuberculosis complex sp. N0145]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7501.48 Da
• Isoelectric Point: 4.3951

>AT126826 WP_009935474.1 NZ_CP040693:1770713-1770916 [Mycobacterium tuberculosis complex sp. N0145]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Nucleotide

• Length: 204 bp

>AT126826 NZ_CP040693:1770713-1770916 [Mycobacterium tuberculosis complex sp. N0145]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Structures

Toxin

• PDB: 6A7V

Antitoxin

• AlphaFold DB: A0A0E8UJ46