Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 1576894..1577549 | Replicon | chromosome |
Accession | NZ_CP040693 | ||
Organism | Mycobacterium tuberculosis complex sp. N0145 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WFA6 |
Locus tag | FF953_RS07440 | Protein ID | WP_003898861.1 |
Coordinates | 1576894..1577295 (-) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TIK2 |
Locus tag | FF953_RS07445 | Protein ID | WP_003407272.1 |
Coordinates | 1577292..1577549 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FF953_RS07425 (FF953_07665) | 1572366..1573751 | - | 1386 | WP_003407260.1 | cytochrome P450 | - |
FF953_RS07430 (FF953_07670) | 1573829..1574863 | + | 1035 | WP_003407264.1 | AraC family transcriptional regulator | - |
FF953_RS07435 (FF953_07675) | 1574909..1576639 | - | 1731 | WP_009940170.1 | PE family protein | - |
FF953_RS07440 (FF953_07680) | 1576894..1577295 | - | 402 | WP_003898861.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FF953_RS07445 (FF953_07685) | 1577292..1577549 | - | 258 | WP_003407272.1 | CopG family transcriptional regulator | Antitoxin |
FF953_RS07450 (FF953_07690) | 1577632..1578591 | - | 960 | WP_003407276.1 | alpha/beta hydrolase | - |
FF953_RS07455 (FF953_07695) | 1578616..1579578 | - | 963 | WP_003905554.1 | alpha/beta hydrolase | - |
FF953_RS07460 (FF953_07700) | 1579577..1580314 | + | 738 | WP_031647000.1 | lysoplasmalogenase | - |
FF953_RS07465 (FF953_07705) | 1580395..1582362 | + | 1968 | WP_003407285.1 | primosomal protein N' | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14952.43 Da Isoelectric Point: 11.4656
>T126824 WP_003898861.1 NZ_CP040693:c1577295-1576894 [Mycobacterium tuberculosis complex sp. N0145]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA
Download Length: 402 bp
>T126824 NZ_CP040693:c1577295-1576894 [Mycobacterium tuberculosis complex sp. N0145]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9443.58 Da Isoelectric Point: 6.4631
>AT126824 WP_003407272.1 NZ_CP040693:c1577549-1577292 [Mycobacterium tuberculosis complex sp. N0145]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS
Download Length: 258 bp
>AT126824 NZ_CP040693:c1577549-1577292 [Mycobacterium tuberculosis complex sp. N0145]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A045ISB0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TIK2 |