Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1576894..1577549 Replicon chromosome
Accession NZ_CP040693
Organism Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag FF953_RS07440 Protein ID WP_003898861.1
Coordinates 1576894..1577295 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag FF953_RS07445 Protein ID WP_003407272.1
Coordinates 1577292..1577549 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF953_RS07425 (FF953_07665) 1572366..1573751 - 1386 WP_003407260.1 cytochrome P450 -
FF953_RS07430 (FF953_07670) 1573829..1574863 + 1035 WP_003407264.1 AraC family transcriptional regulator -
FF953_RS07435 (FF953_07675) 1574909..1576639 - 1731 WP_009940170.1 PE family protein -
FF953_RS07440 (FF953_07680) 1576894..1577295 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
FF953_RS07445 (FF953_07685) 1577292..1577549 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
FF953_RS07450 (FF953_07690) 1577632..1578591 - 960 WP_003407276.1 alpha/beta hydrolase -
FF953_RS07455 (FF953_07695) 1578616..1579578 - 963 WP_003905554.1 alpha/beta hydrolase -
FF953_RS07460 (FF953_07700) 1579577..1580314 + 738 WP_031647000.1 lysoplasmalogenase -
FF953_RS07465 (FF953_07705) 1580395..1582362 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T126824 WP_003898861.1 NZ_CP040693:c1577295-1576894 [Mycobacterium tuberculosis complex sp. N0145]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T126824 NZ_CP040693:c1577295-1576894 [Mycobacterium tuberculosis complex sp. N0145]
ATGATCCTTGTCGACTCCGATGTGCTGATCGCGCATTTGCGGGGTGTCGTTGCTGCTCGCGATTGGCTTGTCAGCGCCCG
CAAGGACGGACCGCTGGCGATCAGCGTGGTGTCCACCGCCGAACTCATCGGCGGAATGCGGACCGCCGAACGGCGCGAGG
TGTGGCGCCTGCTTGCATCGTTTCGGGTACAGCCAGCAACCGAGGTAATCGCACGCCGCGCCGGCGACATGATGCGCCGA
TATCGTCGCAGCCACAACCGGATTGGACTTGGCGACTATCTGATAGCTGCTACCGCCGACGTCCAGGACCTGCAATTGGC
AACCCTCAACGTGTGGCATTTCCCCATGTTCGAGCAGCTGAAACCACCATTTGCGGTGCCGGGGCACCGACCGCGGGCAT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT126824 WP_003407272.1 NZ_CP040693:c1577549-1577292 [Mycobacterium tuberculosis complex sp. N0145]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT126824 NZ_CP040693:c1577549-1577292 [Mycobacterium tuberculosis complex sp. N0145]
ATGAAGCGGACCAACATCTACCTCGACGAGGAGCAGACGGCAAGCCTCGACAAGTTGGCCGCGCAAGAAGGTGTTTCGCG
CGCCGAGCTGATCCGCCTCCTGCTGAACCGAGCCCTCACCACCGCTGGGGACGACCTTGCATCGGACCTGCAGGCTATAA
ACGATTCGTTCGGCACGCTTCGCCACCTGGATCCGCCGGTGCGTCGCTCCGGTGGTCGTGAACAGCACCTTGCCCAGGTG
TGGCGCGCCACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References