Detailed information of TA system TA126822

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1389879..1390438
• Replicon: chromosome
• Accession: NZ_CP040693
• Organism: Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: FF953_RS06625
• Protein ID: WP_003898789.1
• Coordinates: 1389879..1390172 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: FF953_RS06630
• Protein ID: WP_003406322.1
• Coordinates: 1390169..1390438 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF953_RS06600 (FF953_06805)	1385577..1385837	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
FF953_RS06605 (FF953_06810)	1385834..1386265	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
FF953_RS06610 (FF953_06815)	1386288..1387871	-	1584	WP_009940130.1	PE family protein	-
FF953_RS06615 (FF953_06825)	1388051..1388911	+	861	WP_003900301.1	glycine betaine ABC transporter substrate-binding protein	-
FF953_RS06620 (FF953_06830)	1388992..1389822	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
FF953_RS06625 (FF953_06835)	1389879..1390172	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
FF953_RS06630 (FF953_06840)	1390169..1390438	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FF953_RS06635 (FF953_06845)	1390551..1394246	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
FF953_RS06640 (FF953_06850)	1394388..1395176	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T126822 WP_003898789.1 NZ_CP040693:c1390172-1389879 [Mycobacterium tuberculosis complex sp. N0145]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T126822 NZ_CP040693:c1390172-1389879 [Mycobacterium tuberculosis complex sp. N0145]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT126822 WP_003406322.1 NZ_CP040693:c1390438-1390169 [Mycobacterium tuberculosis complex sp. N0145]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT126822 NZ_CP040693:c1390438-1390169 [Mycobacterium tuberculosis complex sp. N0145]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2