Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1230598..1231229 Replicon chromosome
Accession NZ_CP040693
Organism Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag FF953_RS05875 Protein ID WP_003405820.1
Coordinates 1230598..1230909 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag FF953_RS05880 Protein ID WP_003405836.1
Coordinates 1230909..1231229 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF953_RS05855 (FF953_06035) 1226079..1227503 - 1425 WP_003405805.1 class II fumarate hydratase -
FF953_RS05860 (FF953_06040) 1227534..1228622 - 1089 WP_003898726.1 class II fructose-bisphosphatase -
FF953_RS05865 (FF953_06045) 1228678..1229322 + 645 WP_003915494.1 DUF4245 domain-containing protein -
FF953_RS05870 (FF953_06050) 1229329..1230486 - 1158 WP_003898727.1 AI-2E family transporter -
FF953_RS05875 (FF953_06055) 1230598..1230909 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
FF953_RS05880 (FF953_06060) 1230909..1231229 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
FF953_RS05885 (FF953_06065) 1231239..1232775 + 1537 Protein_1159 carboxylesterase/lipase family protein -
FF953_RS05890 (FF953_06070) 1232782..1233894 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
FF953_RS05895 (FF953_06075) 1233904..1234161 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
FF953_RS05900 (FF953_06080) 1234151..1235398 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
FF953_RS05905 (FF953_06085) 1235395..1236033 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T126819 WP_003405820.1 NZ_CP040693:c1230909-1230598 [Mycobacterium tuberculosis complex sp. N0145]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T126819 NZ_CP040693:c1230909-1230598 [Mycobacterium tuberculosis complex sp. N0145]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT126819 WP_003405836.1 NZ_CP040693:c1231229-1230909 [Mycobacterium tuberculosis complex sp. N0145]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT126819 NZ_CP040693:c1231229-1230909 [Mycobacterium tuberculosis complex sp. N0145]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References