Detailed information of TA system TA126811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-PHD
• Location: 716606..717270
• Replicon: chromosome
• Accession: NZ_CP040693
• Organism: Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P96917
• Locus tag: FF953_RS03275
• Protein ID: WP_003403246.1
• Coordinates: 716863..717270 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P9WF18
• Locus tag: FF953_RS03270
• Protein ID: WP_003403244.1
• Coordinates: 716606..716866 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF953_RS03245 (FF953_03325)	712783..713847	+	1065	WP_003898532.1	zinc ribbon domain-containing protein	-
FF953_RS03250 (FF953_03330)	713951..714898	+	948	WP_003403232.1	DUF732 domain-containing protein	-
FF953_RS03255 (FF953_03335)	714991..715245	+	255	WP_003403235.1	type II toxin-antitoxin system antitoxin VapB30	-
FF953_RS03260 (FF953_03340)	715245..715640	+	396	WP_003403236.1	type II toxin-antitoxin system toxin ribonuclease C30	-
FF953_RS03265 (FF953_03345)	715734..716474	-	741	WP_003403239.1	TVP38/TMEM64 family protein	-
FF953_RS03270 (FF953_03350)	716606..716866	+	261	WP_003403244.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FF953_RS03275 (FF953_03355)	716863..717270	+	408	WP_003403246.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF953_RS03280 (FF953_03360)	717342..718493	-	1152	WP_003403248.1	FIST N-terminal domain-containing protein	-
FF953_RS03285 (FF953_03365)	718586..720313	-	1728	WP_003901883.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14376.37 Da
• Isoelectric Point: 4.3568

>T126811 WP_003403246.1 NZ_CP040693:716863-717270 [Mycobacterium tuberculosis complex sp. N0145]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Nucleotide

• Length: 408 bp

>T126811 NZ_CP040693:716863-717270 [Mycobacterium tuberculosis complex sp. N0145]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9492.84 Da
• Isoelectric Point: 11.9108

>AT126811 WP_003403244.1 NZ_CP040693:716606-716866 [Mycobacterium tuberculosis complex sp. N0145]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Nucleotide

• Length: 261 bp

>AT126811 NZ_CP040693:716606-716866 [Mycobacterium tuberculosis complex sp. N0145]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Structures

Toxin

• PDB: 3DBO

Antitoxin

• AlphaFold DB: A0A7U4BSE4