Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709363..709988 Replicon chromosome
Accession NZ_CP040693
Organism Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag FF953_RS03225 Protein ID WP_003403218.1
Coordinates 709587..709988 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag FF953_RS03220 Protein ID WP_003403213.1
Coordinates 709363..709590 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF953_RS03195 (FF953_03265) 704542..704763 - 222 WP_003898525.1 DUF4926 domain-containing protein -
FF953_RS03200 (FF953_03270) 704905..705510 + 606 WP_003898526.1 hypothetical protein -
FF953_RS03205 (FF953_03275) 705529..708096 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
FF953_RS03210 (FF953_03280) 708180..708929 + 750 WP_003898528.1 hypothetical protein -
FF953_RS03215 (FF953_03285) 708926..709168 + 243 WP_003403210.1 hypothetical protein -
FF953_RS03220 (FF953_03295) 709363..709590 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
FF953_RS03225 (FF953_03300) 709587..709988 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
FF953_RS03230 710117..710200 + 84 Protein_640 galactose-1-phosphate uridylyltransferase -
FF953_RS03235 710219..711300 + 1082 Protein_641 galactose-1-phosphate uridylyltransferase -
FF953_RS03240 (FF953_03315) 711297..712388 + 1092 WP_003900977.1 galactokinase -
FF953_RS03245 (FF953_03325) 712783..713847 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
FF953_RS03250 (FF953_03330) 713951..714898 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T126809 WP_003403218.1 NZ_CP040693:709587-709988 [Mycobacterium tuberculosis complex sp. N0145]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T126809 NZ_CP040693:709587-709988 [Mycobacterium tuberculosis complex sp. N0145]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT126809 WP_003403213.1 NZ_CP040693:709363-709590 [Mycobacterium tuberculosis complex sp. N0145]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT126809 NZ_CP040693:709363-709590 [Mycobacterium tuberculosis complex sp. N0145]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References