Detailed information of TA system TA126802

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 362439..363082
• Replicon: chromosome
• Accession: NZ_CP040693
• Organism: Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WFB8
• Locus tag: FF953_RS01575
• Protein ID: WP_003401566.1
• Coordinates: 362657..363082 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: O07227
• Locus tag: FF953_RS01570
• Protein ID: WP_003401563.1
• Coordinates: 362439..362660 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF953_RS01545 (FF953_01580)	357558..358361	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
FF953_RS01550 (FF953_01585)	358371..359768	-	1398	WP_003401544.1	sulfatase	-
FF953_RS01555 (FF953_01590)	359947..361722	+	1776	WP_010886074.1	PE family protein	-
FF953_RS01560 (FF953_01595)	361865..362092	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	-
FF953_RS01565 (FF953_01600)	362089..362391	+	303	WP_003401560.1	toxin-antitoxin system toxin	-
FF953_RS01570 (FF953_01605)	362439..362660	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	Antitoxin
FF953_RS01575 (FF953_01610)	362657..363082	+	426	WP_003401566.1	PIN domain nuclease	Toxin
FF953_RS01580 (FF953_01615)	363218..363850	+	633	WP_003905275.1	TetR/AcrR family transcriptional regulator	-
FF953_RS01585 (FF953_01620)	363847..364755	+	909	WP_003900117.1	protochlorophyllide reductase	-
FF953_RS01590	364763..365353	-	591	WP_229298012.1	hypothetical protein	-
FF953_RS01595	365346..365396	-	51	Protein_315	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-125)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-37)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15713.90 Da
• Isoelectric Point: 5.6002

>T126802 WP_003401566.1 NZ_CP040693:362657-363082 [Mycobacterium tuberculosis complex sp. N0145]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Nucleotide

• Length: 426 bp

>T126802 NZ_CP040693:362657-363082 [Mycobacterium tuberculosis complex sp. N0145]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8088.31 Da
• Isoelectric Point: 10.7177

>AT126802 WP_003401563.1 NZ_CP040693:362439-362660 [Mycobacterium tuberculosis complex sp. N0145]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Nucleotide

• Length: 222 bp

>AT126802 NZ_CP040693:362439-362660 [Mycobacterium tuberculosis complex sp. N0145]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Structures

Toxin

• PDB: 3H87

Antitoxin

• AlphaFold DB: A0A829CG48