Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Rv0298-Rv0299/- |
Location | 361865..362391 | Replicon | chromosome |
Accession | NZ_CP040693 | ||
Organism | Mycobacterium tuberculosis complex sp. N0145 |
Toxin (Protein)
Gene name | Rv0299 | Uniprot ID | - |
Locus tag | FF953_RS01565 | Protein ID | WP_003401560.1 |
Coordinates | 362089..362391 (+) | Length | 101 a.a. |
Antitoxin (Protein)
Gene name | Rv0298 | Uniprot ID | P9WJ08 |
Locus tag | FF953_RS01560 | Protein ID | WP_003401555.1 |
Coordinates | 361865..362092 (+) | Length | 76 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FF953_RS01545 (FF953_01580) | 357558..358361 | - | 804 | WP_003401540.1 | Stf0 family sulphotransferase | - |
FF953_RS01550 (FF953_01585) | 358371..359768 | - | 1398 | WP_003401544.1 | sulfatase | - |
FF953_RS01555 (FF953_01590) | 359947..361722 | + | 1776 | WP_010886074.1 | PE family protein | - |
FF953_RS01560 (FF953_01595) | 361865..362092 | + | 228 | WP_003401555.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
FF953_RS01565 (FF953_01600) | 362089..362391 | + | 303 | WP_003401560.1 | toxin-antitoxin system toxin | Toxin |
FF953_RS01570 (FF953_01605) | 362439..362660 | + | 222 | WP_003401563.1 | type II toxin-antitoxin system antitoxin VapB2 | - |
FF953_RS01575 (FF953_01610) | 362657..363082 | + | 426 | WP_003401566.1 | PIN domain nuclease | - |
FF953_RS01580 (FF953_01615) | 363218..363850 | + | 633 | WP_003905275.1 | TetR/AcrR family transcriptional regulator | - |
FF953_RS01585 (FF953_01620) | 363847..364755 | + | 909 | WP_003900117.1 | protochlorophyllide reductase | - |
FF953_RS01590 | 364763..365353 | - | 591 | WP_229298012.1 | hypothetical protein | - |
FF953_RS01595 | 365346..365396 | - | 51 | Protein_315 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 10442.16 Da Isoelectric Point: 4.9609
>T126800 WP_003401560.1 NZ_CP040693:362089-362391 [Mycobacterium tuberculosis complex sp. N0145]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC
Download Length: 303 bp
>T126800 NZ_CP040693:362089-362391 [Mycobacterium tuberculosis complex sp. N0145]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8130.21 Da Isoelectric Point: 7.0084
>AT126800 WP_003401555.1 NZ_CP040693:361865-362092 [Mycobacterium tuberculosis complex sp. N0145]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS
Download Length: 228 bp
>AT126800 NZ_CP040693:361865-362092 [Mycobacterium tuberculosis complex sp. N0145]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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