126800

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 361865..362391 Replicon chromosome
Accession NZ_CP040693
Organism Mycobacterium tuberculosis complex sp. N0145

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag FF953_RS01565 Protein ID WP_003401560.1
Coordinates 362089..362391 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag FF953_RS01560 Protein ID WP_003401555.1
Coordinates 361865..362092 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF953_RS01545 (FF953_01580) 357558..358361 - 804 WP_003401540.1 Stf0 family sulphotransferase -
FF953_RS01550 (FF953_01585) 358371..359768 - 1398 WP_003401544.1 sulfatase -
FF953_RS01555 (FF953_01590) 359947..361722 + 1776 WP_010886074.1 PE family protein -
FF953_RS01560 (FF953_01595) 361865..362092 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
FF953_RS01565 (FF953_01600) 362089..362391 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
FF953_RS01570 (FF953_01605) 362439..362660 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
FF953_RS01575 (FF953_01610) 362657..363082 + 426 WP_003401566.1 PIN domain nuclease -
FF953_RS01580 (FF953_01615) 363218..363850 + 633 WP_003905275.1 TetR/AcrR family transcriptional regulator -
FF953_RS01585 (FF953_01620) 363847..364755 + 909 WP_003900117.1 protochlorophyllide reductase -
FF953_RS01590 364763..365353 - 591 WP_229298012.1 hypothetical protein -
FF953_RS01595 365346..365396 - 51 Protein_315 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(6-41)


Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T126800 WP_003401560.1 NZ_CP040693:362089-362391 [Mycobacterium tuberculosis complex sp. N0145]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T126800 NZ_CP040693:362089-362391 [Mycobacterium tuberculosis complex sp. N0145]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT126800 WP_003401555.1 NZ_CP040693:361865-362092 [Mycobacterium tuberculosis complex sp. N0145]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT126800 NZ_CP040693:361865-362092 [Mycobacterium tuberculosis complex sp. N0145]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGAGCGGCCGGAAGTTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References