Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4338609..4339242 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag FF956_RS20235 Protein ID WP_003400580.1
Coordinates 4338609..4339010 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag FF956_RS20240 Protein ID WP_003400577.1
Coordinates 4339003..4339242 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS20220 (FF956_21085) 4334619..4335530 - 912 WP_003899798.1 SDR family NAD(P)-dependent oxidoreductase -
FF956_RS20225 (FF956_21090) 4335633..4336202 + 570 WP_003902834.1 TetR/AcrR family transcriptional regulator -
FF956_RS20230 (FF956_21095) 4336320..4338557 + 2238 WP_003899797.1 NADP-dependent isocitrate dehydrogenase -
FF956_RS20235 (FF956_21100) 4338609..4339010 - 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
FF956_RS20240 (FF956_21105) 4339003..4339242 - 240 WP_003400577.1 antitoxin VapB1 Antitoxin
FF956_RS20245 (FF956_21110) 4339309..4342248 - 2940 WP_003901785.1 UPF0182 family protein -
FF956_RS20250 (FF956_21115) 4342289..4342450 - 162 WP_003899796.1 hypothetical protein -
FF956_RS20255 (FF956_21120) 4342506..4343945 - 1440 WP_003902831.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T126798 WP_003400580.1 NZ_CP040692:c4339010-4338609 [Mycobacterium tuberculosis complex sp. N0157]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

>T126798 NZ_CP040692:c4339010-4338609 [Mycobacterium tuberculosis complex sp. N0157]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT126798 WP_003400577.1 NZ_CP040692:c4339242-4339003 [Mycobacterium tuberculosis complex sp. N0157]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp

>AT126798 NZ_CP040692:c4339242-4339003 [Mycobacterium tuberculosis complex sp. N0157]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHM7

References