Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4043226..4043869 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag FF956_RS18990 Protein ID WP_003401566.1
Coordinates 4043226..4043651 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag FF956_RS18995 Protein ID WP_003401563.1
Coordinates 4043648..4043869 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS18980 (FF956_19825) 4041553..4042461 - 909 WP_003900117.1 protochlorophyllide reductase -
FF956_RS18985 (FF956_19830) 4042458..4043090 - 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
FF956_RS18990 (FF956_19835) 4043226..4043651 - 426 WP_003401566.1 PIN domain nuclease Toxin
FF956_RS18995 (FF956_19840) 4043648..4043869 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
FF956_RS19000 (FF956_19845) 4043917..4044219 - 303 WP_003401560.1 toxin-antitoxin system toxin -
FF956_RS19005 (FF956_19850) 4044216..4044443 - 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
FF956_RS19010 (FF956_19855) 4044586..4046232 - 1647 WP_031654185.1 PE family protein -
FF956_RS19015 (FF956_19860) 4046411..4047808 + 1398 Protein_3754 sulfatase -
FF956_RS19020 (FF956_19865) 4047818..4048621 + 804 WP_003401540.1 Stf0 family sulphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T126795 WP_003401566.1 NZ_CP040692:c4043651-4043226 [Mycobacterium tuberculosis complex sp. N0157]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

>T126795 NZ_CP040692:c4043651-4043226 [Mycobacterium tuberculosis complex sp. N0157]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT126795 WP_003401563.1 NZ_CP040692:c4043869-4043648 [Mycobacterium tuberculosis complex sp. N0157]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp

>AT126795 NZ_CP040692:c4043869-4043648 [Mycobacterium tuberculosis complex sp. N0157]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References