Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3962602..3963613 Replicon chromosome
Accession NZ_CP040692
Organism Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag FF956_RS18670 Protein ID WP_003401859.1
Coordinates 3963020..3963613 (+) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag FF956_RS18665 Protein ID WP_003401860.1
Coordinates 3962602..3962991 (+) Length 130 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF956_RS18640 (FF956_19485) 3958450..3959205 + 756 WP_003401865.1 XdhC family protein -
FF956_RS18645 (FF956_19490) 3959202..3959795 + 594 WP_003902973.1 NTP transferase domain-containing protein -
FF956_RS18650 (FF956_19495) 3959792..3960688 + 897 WP_003902972.1 MoxR family ATPase -
FF956_RS18655 (FF956_19500) 3960702..3961304 + 603 WP_003898417.1 SRPBCC family protein -
FF956_RS18660 (FF956_19505) 3961310..3962521 + 1212 WP_003908517.1 VWA domain-containing protein -
FF956_RS18665 (FF956_19510) 3962602..3962991 + 390 WP_003401860.1 hypothetical protein Antitoxin
FF956_RS18670 (FF956_19515) 3963020..3963613 + 594 WP_003401859.1 zeta toxin family protein Toxin
FF956_RS18675 (FF956_19520) 3963638..3964768 + 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
FF956_RS18680 (FF956_19525) 3964757..3965440 - 684 WP_003401857.1 VTT domain-containing protein -
FF956_RS18685 (FF956_19530) 3965536..3966570 + 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
FF956_RS18690 (FF956_19535) 3966582..3967964 - 1383 WP_003908516.1 magnesium transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T126794 WP_003401859.1 NZ_CP040692:3963020-3963613 [Mycobacterium tuberculosis complex sp. N0157]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T126794 NZ_CP040692:3963020-3963613 [Mycobacterium tuberculosis complex sp. N0157]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT126794 WP_003401860.1 NZ_CP040692:3962602-3962991 [Mycobacterium tuberculosis complex sp. N0157]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT126794 NZ_CP040692:3962602-3962991 [Mycobacterium tuberculosis complex sp. N0157]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8


Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References