Detailed information of TA system TA126793

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-CcdA
• Location: 3773183..3773859
• Replicon: chromosome
• Accession: NZ_CP040692
• Organism: Mycobacterium tuberculosis complex sp. N0157

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TPQ9
• Locus tag: FF956_RS17730
• Protein ID: WP_003898500.1
• Coordinates: 3773446..3773859 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TPR0
• Locus tag: FF956_RS17725
• Protein ID: WP_003402915.1
• Coordinates: 3773183..3773449 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FF956_RS17710 (FF956_18510)	3768617..3769597	-	981	WP_003402923.1	o-succinylbenzoate synthase	-
FF956_RS17715 (FF956_18515)	3769594..3771198	-	1605	WP_003903056.1	amidohydrolase	-
FF956_RS17720 (FF956_18520)	3771276..3772991	+	1716	WP_003903055.1	fatty-acid--CoA ligase FadD8	-
FF956_RS17725 (FF956_18525)	3773183..3773449	+	267	WP_003402915.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
FF956_RS17730 (FF956_18530)	3773446..3773859	+	414	WP_003898500.1	type II toxin-antitoxin system VapC family toxin	Toxin
FF956_RS17735 (FF956_18535)	3774173..3775075	+	903	WP_031654206.1	1,4-dihydroxy-2-naphthoyl-CoA synthase	-
FF956_RS17740 (FF956_18540)	3775171..3776055	+	885	WP_003903053.1	SDR family oxidoreductase	-
FF956_RS17745 (FF956_18545)	3776118..3776504	+	387	WP_003402907.1	VOC family protein	-
FF956_RS17750 (FF956_18550)	3776624..3777877	+	1254	WP_003402904.1	inorganic phosphate transporter	-
FF956_RS17755 (FF956_18555)	3777874..3778152	+	279	WP_003402901.1	hypothetical protein	-
FF956_RS17760 (FF956_18560)	3778212..3778514	+	303	WP_003402896.1	DUF3349 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (13-129)

Antitoxin

• Post-segregation antitoxin CcdA (19-61)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14667.78 Da
• Isoelectric Point: 7.3603

>T126793 WP_003898500.1 NZ_CP040692:3773446-3773859 [Mycobacterium tuberculosis complex sp. N0157]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Nucleotide

• Length: 414 bp

>T126793 NZ_CP040692:3773446-3773859 [Mycobacterium tuberculosis complex sp. N0157]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9543.79 Da
• Isoelectric Point: 4.5994

>AT126793 WP_003402915.1 NZ_CP040692:3773183-3773449 [Mycobacterium tuberculosis complex sp. N0157]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Nucleotide

• Length: 267 bp

>AT126793 NZ_CP040692:3773183-3773449 [Mycobacterium tuberculosis complex sp. N0157]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Structures

Toxin

• AlphaFold DB: G0TPQ9

Antitoxin

• AlphaFold DB: G0TPR0