Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/AbrB(antitoxin) |
| Location | 3718982..3719628 | Replicon | chromosome |
| Accession | NZ_CP040692 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0157 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | G0TQ88 |
| Locus tag | FF956_RS17490 | Protein ID | WP_003403137.1 |
| Coordinates | 3719215..3719628 (+) | Length | 138 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TQ89 |
| Locus tag | FF956_RS17485 | Protein ID | WP_003403139.1 |
| Coordinates | 3718982..3719218 (+) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF956_RS17450 (FF956_18245) | 3714056..3714766 | - | 711 | Protein_3443 | IS607 family element RNA-guided endonuclease TnpB | - |
| FF956_RS17455 (FF956_18250) | 3714768..3715352 | - | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
| FF956_RS17460 (FF956_18255) | 3715593..3716543 | - | 951 | WP_003907436.1 | DUF1259 domain-containing protein | - |
| FF956_RS17465 (FF956_18260) | 3716615..3716926 | - | 312 | WP_003403164.1 | hypothetical protein | - |
| FF956_RS17470 (FF956_18265) | 3717049..3717744 | + | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
| FF956_RS17475 (FF956_18270) | 3717728..3718258 | + | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
| FF956_RS17480 (FF956_18275) | 3718372..3718878 | + | 507 | WP_003900973.1 | two component system sensor kinase HK1 | - |
| FF956_RS17485 (FF956_18280) | 3718982..3719218 | + | 237 | WP_003403139.1 | type II toxin-antitoxin system antitoxin VapB27 | Antitoxin |
| FF956_RS17490 (FF956_18285) | 3719215..3719628 | + | 414 | WP_003403137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| FF956_RS17495 (FF956_18290) | 3719879..3721114 | + | 1236 | WP_003403128.1 | ATP-binding protein | - |
| FF956_RS17500 (FF956_18295) | 3721297..3721554 | + | 258 | WP_003403125.1 | type II toxin-antitoxin system antitoxin VapB4 | - |
| FF956_RS17505 (FF956_18300) | 3721551..3721943 | + | 393 | WP_003403122.1 | type II toxin-antitoxin system toxin ribonuclease C4 | - |
| FF956_RS17510 (FF956_18305) | 3721995..3723545 | - | 1551 | WP_003403119.1 | MlaD family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14786.14 Da Isoelectric Point: 8.1405
>T126790 WP_003403137.1 NZ_CP040692:3719215-3719628 [Mycobacterium tuberculosis complex sp. N0157]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
Download Length: 414 bp
>T126790 NZ_CP040692:3719215-3719628 [Mycobacterium tuberculosis complex sp. N0157]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8212.41 Da Isoelectric Point: 5.0351
>AT126790 WP_003403139.1 NZ_CP040692:3718982-3719218 [Mycobacterium tuberculosis complex sp. N0157]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK
Download Length: 237 bp
>AT126790 NZ_CP040692:3718982-3719218 [Mycobacterium tuberculosis complex sp. N0157]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|