Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
| Location | 3712895..3713538 | Replicon | chromosome |
| Accession | NZ_CP040692 | ||
| Organism | Mycobacterium tuberculosis complex sp. N0157 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P67239 |
| Locus tag | FF956_RS17435 | Protein ID | WP_003403187.1 |
| Coordinates | 3712895..3713296 (-) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TQ91 |
| Locus tag | FF956_RS17440 | Protein ID | WP_003403184.1 |
| Coordinates | 3713293..3713538 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FF956_RS17410 (FF956_18195) | 3709853..3710458 | - | 606 | WP_003898526.1 | hypothetical protein | - |
| FF956_RS17415 (FF956_18200) | 3710600..3710821 | + | 222 | WP_003898525.1 | DUF4926 domain-containing protein | - |
| FF956_RS17420 (FF956_18205) | 3710873..3712030 | + | 1158 | Protein_3437 | hypothetical protein | - |
| FF956_RS17425 (FF956_18210) | 3712110..3712307 | + | 198 | WP_003403191.1 | hypothetical protein | - |
| FF956_RS17430 (FF956_18225) | 3712725..3712904 | - | 180 | Protein_3439 | hypothetical protein | - |
| FF956_RS17435 (FF956_18230) | 3712895..3713296 | - | 402 | WP_003403187.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| FF956_RS17440 (FF956_18235) | 3713293..3713538 | - | 246 | WP_003403184.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| FF956_RS17445 (FF956_18240) | 3713583..3714053 | - | 471 | WP_003898523.1 | hypothetical protein | - |
| FF956_RS17450 (FF956_18245) | 3714056..3714766 | - | 711 | Protein_3443 | IS607 family element RNA-guided endonuclease TnpB | - |
| FF956_RS17455 (FF956_18250) | 3714768..3715352 | - | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
| FF956_RS17460 (FF956_18255) | 3715593..3716543 | - | 951 | WP_003907436.1 | DUF1259 domain-containing protein | - |
| FF956_RS17465 (FF956_18260) | 3716615..3716926 | - | 312 | WP_003403164.1 | hypothetical protein | - |
| FF956_RS17470 (FF956_18265) | 3717049..3717744 | + | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
| FF956_RS17475 (FF956_18270) | 3717728..3718258 | + | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14501.21 Da Isoelectric Point: 4.4463
>T126789 WP_003403187.1 NZ_CP040692:c3713296-3712895 [Mycobacterium tuberculosis complex sp. N0157]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
Download Length: 402 bp
>T126789 NZ_CP040692:c3713296-3712895 [Mycobacterium tuberculosis complex sp. N0157]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA
Antitoxin
Download Length: 82 a.a. Molecular weight: 8813.12 Da Isoelectric Point: 10.3486
>AT126789 WP_003403184.1 NZ_CP040692:c3713538-3713293 [Mycobacterium tuberculosis complex sp. N0157]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A
Download Length: 246 bp
>AT126789 NZ_CP040692:c3713538-3713293 [Mycobacterium tuberculosis complex sp. N0157]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSD6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TQ91 |